| 王春亚,李佳媚,赵玉杰,等.三酰甘油水平与危重症病人预后的相关性分析[J].安徽医药,2020,24(5):938-941. |
| 三酰甘油水平与危重症病人预后的相关性分析 |
| Correlation between triglyceride level and prognosis of critically ill patients |
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| DOI：10.3969/j.issn.1009?6469.2020.05.023 |
| 中文关键词: 三酰甘油 危重症 预后 Logistic模型 |
| 英文关键词: Triglyceride Critical illness Prognosis Logistic models |
| 基金项目:陕西省社发攻关项目(S2018?YF?YBSF?0337) |
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| 中文摘要: |
| 目的探讨三酰甘油( TG)水平与危重症病人预后的相关关系。方法采用回顾性队列研究，纳入 2018年 1月至 2019年 1月西安交通大学第二附属医院单次收住成年重症监护病房( ICU)的病人 1 207例，提取病人的年龄、性别、种族、合并症、首次序贯器官衰竭评分( SOFA)、 24 h内 TG值等，将病人按 TG的三分位间距数分为高 TG组，中 TG组和低 TG组，比较三组的基线资料；将病人是否在 ICU死亡及 TG水平分别作为因变量和自变量纳入 logistic回归模型并在不同性别病人中进行亚组分析。结果共纳入病例数 1 207例，其中死亡组 120例( 9.9%)存活组 1 087例，经多因素 logistic回归分析发现 SOFA评分( OR＝1.346，95%CI:1.278~1.417，P＜0.001)及 TG水平与危重病人预后独立相关，其中高 TG组病人死亡风险低于低 TG组( OR＝1.883，95%CI:1.093~3.245，P＝0.023)；进一步采用多因素 logistic回归分析不同性别病人预后的危险因素，结果发现 SOFA评分仍是两类病人的独立危险因素(男性 OR＝1.439，95%CI:1.333~1.554，P＜0.001；女性 OR＝1.255，95%CI:1.167~1.351，P＜0.001)；而 TG水平仅与男性病人的预后独立相关，其中高 TG组病人死亡风险低于低 TG组( OR＝2.377，95%CI:1.039~5.434， P＝0.040)。结论 TG水平与危重病人预后独立相关，且入科 TG水平越高，病人死亡风险越低。 |
| 英文摘要: |
| Objective To explore the correlation between the level of triglyceride(TG)and the prognosis of critically ill patients. Methods A retrospective cohort study was conducted，including 1 207 patients admitted to the intensive care unit(ICU)in the Second Affiliated Hospital of Xi’an JiaotongUniversity from January 2018 to January 2019.The information of age，gender，race， complications，first SOFA score and TG level within 24 hours were extracted.The patients were divided into high TG group，middle TG group and low TG group according to the triple range of TG.The baseline data of three groups were compared.The ICU mortalityand the TG level were used as the dependent variables and independent variables respectively in multivariate logistic regressionand confounding factors were controlled.Results A total of 1207 cases were included，including 120 cases in the death group(9.9%)and 1087 in the survival group.Multivariate logistic regression analysis showed that SOFA score(OR＝1.346，95%CI:1.278?1.417，P＜0.001)and TG level were independently related to the prognosis of critical ill patients，and the risk of mortality in the high TG group was lower than that in the low TG group(OR＝1.883，95%CI:1.093?3.245，P＝0.023).In subgroups，the results showed that SOFA score was still an independent risk factor for two groups of patients(male OR＝1.439，95%CI:1.333?1.554，P＜0.001；female OR＝1.255，95%CI:1.167?1.351，P＜0.001)； while the level of TG was only independently related to the prognosis of male patients，and the risk of mortality in the high TG group was lower than that in the low TG group(OR＝2.377，95%CI:1.039?5.434，P＝0.040).Conclusion The level of TG is independently related to the prognosis of critically ill patients，and high triglyc? eride level is associated with low mortality. |
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