| 杨曼春,曹小勇.血清和腹腔液糖类抗原 125水平与子宫内膜异位症 r?AFS分期的相关性[J].安徽医药,2020,24(5):959-963. |
| 血清和腹腔液糖类抗原 125水平与子宫内膜异位症 r?AFS分期的相关性 |
| Correlation between serum and peritoneal fluid CA125 levels and r?AFS staging of endometriosis |
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| DOI：10.3969/j.issn.1009?6469.2020.05.028 |
| 中文关键词: 子宫内膜异位症 CA?125抗原 肿瘤坏死因子 α 血清 腹水 相关性 |
| 英文关键词: Endometriosis CA?125 antigen Tumor necrosis factor α Serum Ascites Correlation CA125inperitonealfluidwaspositivelycorrelated, |
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| 中文摘要: |
| 目的分析血清和腹腔液中糖类抗原 125(CA125)水平与子宫内膜异位症( EM)疾病分期的相关性。方法纳入 2017年 1月至 2018年 5月荥阳市中医院 EM病人 89例及非 EM病人 80例，参考美国生育学会提出的修正 EM分期法( r?AFS)对 EM病人分期。术前采集 EM病人血清，术中采集其腹腔液，入组时采集非 EM病人血清，检测 CA125、血管内皮生长因子( VEGF)、细胞介素 ?6(IL?6)、肿瘤坏死因子 α(TNF?α)水平。分析各指标间的相关性，通过 logistic回归分析 CA125与其它检测指标是否白为 r?AFS分期影响因素。结果血清 CA125水平对比， EM Ⅳ期＞EM Ⅲ期组＞EM Ⅱ期组、 EM Ⅰ期组及非 EM组，且 EM Ⅱ期组＞非 EM组；腹腔液 CA125水平对比， EM Ⅳ期组＞ EM Ⅲ期组＞ EM Ⅱ期组、 EM Ⅰ期组及非 EM组，上述均差异有统计学意义( P＜0.05)。 EM病人血清 CA125与腹腔液 CA125呈正相关( P＜0.05)；血清 CA125与血清 VEGF、IL?6及 TNF?α均呈正相关 |
| 英文摘要: |
| Objective To analyze the correlation between serum and peritoneal fluid carbohydrate antigen 125(CA125)and the stage of endometriosis(EM).Methods Eighty?nine patients with EM and eighty non?EM patients enrolled by The Traditional Chi?nese Medical Hospital of Xingyang from Jan.2017 to May 2018 were collected in the study.The revised American Fertility Societyclassification(r?AFS)was used for the staging of EM.The serum of EM patients was collected before operation，and the peritoneal fluid was collected during operation，the serum of non?EM patients was collected after enrollment.The levels of CA125，vascular en? dothelial growth factor(VEGF)，interleukin?6(IL?6)and tumor necrosis factor?α(TNF?α)were tested.The correlations between each index were analyzed.Logistic regression was used to analyze whether CA125 and other indexes were the influencing factors of r?AFS staging.Results The result of serum CA125 level comparison were EM stage Ⅳ group＞EM stage Ⅲ group＞EM stage Ⅱ group，EM stage I group and non?EM group，and EM stage Ⅱ group＞non?EM group.The result of peritoneal fluid comparison were EM stage Ⅳ group＞EM stage Ⅲ group＞EM stage Ⅱ group，EM stage I group and non?EM group.The differences were statistical? ly significant(P＜0.05).In EM patients，serum CA125 was positively correlated with CA125 in peritoneal fluid(P＜0.05)serum CA125 was positively correlated with serum VEGF，IL?6 and TNF?α(P＜0.05)， with VEGF，IL?6 and TNF?α in peritoneal fluid(P＜0.05).Serum and peritoneal fluid CA125 were positively correlated with EM stage(P＜0.05).Serum CA125 and the interaction between serum CA125 and TNF?α were both independent risk factors for high stage r?AFS(P＜0.05).Conclusion Both of the serum and peritoneal fluid CA125 increased with the increase of r?AFS stage in patients with EM，and were effective in differentiating stage Ⅲ?Ⅳ from stage Ⅰ?Ⅱ.Serum CA125 may affect the development ofEM by synergistic effect with TNF?α. |
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