| 党莎杰,卫文博,卫凌.普瑞巴林联合 B超引导胸椎旁神经阻滞治疗带状疱疹后神经痛 30例[J].安徽医药,2020,24(6):1117-1120. |
| 普瑞巴林联合 B超引导胸椎旁神经阻滞治疗带状疱疹后神经痛 30例 |
| 30 cases of postherpetic neuralgia with pregabalin combined with B?ultrasound guided thoracic paravertebral nerve block |
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| DOI：10.3969/j.issn.1009?6469.2020.06.014 |
| 中文关键词: 神经痛，带状疱疹后 自主神经传导阻滞 胸椎 超声检查，介入性 普瑞巴林 |
| 英文关键词: Neuralgia,postherpetic Autonomic nerve block Thoracic vertebrae Ultrasonography,interventional Pregabalin |
| 基金项目:陕西省科技厅自然科学基础研究计划项目( 2018JM7038) |
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| 中文摘要: |
| 目的分析普瑞巴林联合 B超引导下胸椎旁神经阻滞治疗带状疱疹后神经痛的有效性与安全性。方法选择 2017年1月至2018年8月陕西省杨凌示范区医院疼痛科收治的 60例胸背段带状疱疹后神经痛病人为研究对象，随机数字表法分为对照组和观察组，各30例。对照组采用单纯口服普瑞巴林，第1~2天每次 75 mg，2次/天；第3天开始每次 150 mg，2次/天。疗程 4周，治疗期间停用其他镇痛药。观察组采用口服普瑞巴林联合 B超引导下胸椎旁神经阻滞治疗，普瑞巴林用法同对照组，超声引导下向每个受累神经根分别注射混合药液 5 mL(复方倍他米松 1 mL+腺苷钴胺 1.0 mg+2%利多卡因 2 mL+0.9%氯化钠溶液稀释至 10 mL)，每周 1次，连续 4周。比较两组治疗前及治疗后 1周、 2周、 3周、 4周、 5周后的视觉模拟评分法( VAS)评分和匹兹堡睡眠质量指数(PSQI)，治疗后 5周的疼痛缓解度，治疗有效率以及不良反应发生情况。结果对照组和观察组治疗后较治疗前的 VAS评分和 PSQI均降低，差异有统计学意义(P＜0.05)对照组与观察组治疗前 VAS评分和 PSQI差异无统计学意义(P＞0.05)；观察组治疗后 1 |
| 英文摘要: |
| Objective To analyze the efficacy and safety of pregabalin combined with B?ultrasound guided thoracic paraspinalnerve block in the treatment of postherpetic neuralgia.Methods A total of sixty patients with postherpetic neuralgia in Department of Pain，Yang Ling Demonstration Zone Hospital of Shaanxi Province from January 2017 to August 2018 were selected as the re?search subjects.They were randomly assigned into control group and observation group according to random number method，with 30 cases in each group.The control group was only treated oral pregabalin，twice a day with 75 mg in the first and second day，and twice a day with 150 mg from the third day.The control group was treated for 4 weeks without other analgesics during treatment.The observation group was treated with pregabalin combined with B?ultrasound guided thoracic paravertebral nerve block:the usage of pregabalin was consistent with that of the control group，and 5 mL of the mixture was injected into each affected nerve root un?der ultrasound guidance (1 mL compound betamethasone +1.0 mg adenosine cobalt amine +2 mL 2% lidocaine，with 0.9% sodium chloride solution diluted to 10 mL)，once a week for 4 straight weeks.The Visual analogue scales(VAS)and Pittsburgh Sleep quali? ty Index(PSQI)at the time of pre?treatment and 1，2，3，4 and 5 weeks of post?treatment were compared between the two groups. The degree of pain relief，the total effective rate and adverse reactions at 5 weeks of post?treatment were also recorded.Results The VAS score and PSQI at any time of post?treatment were significantly lower than those at the time of pre?treatment in both groups，and the difference was statistically significant(P＜0.05).There was no significant difference in VAS score and PSQI in both groups at the time of pre?treatment(P＞0.05).The VAS score and PSQI in observation group was significantly lower than that in control group at 1，2，3，4 and 5 weeks of post?treatment(P＜0.05).There was a significant difference in the degree of pain relief between the two groups at 5 weeks of post?treatment(P＜0.05). The total effective rate in observation group was 86.7%，which was significantly higher than 56.7% in control group at 5 weeks of post?treatment(P＜0.05)，but there was no significant difference in ad? verse reactions between the two groups(P＞0.05).Conclusion Pregabalin combined with B?ultrasound guided thoracic paraverte?bral nerve block can effectively relieve the postherpetic neuralgia and improve the sleep quality，which is safe，accurate and effective. |
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