| 任宏娜,孙惠敏,吕志超,等.芩连翘皮方对老年铜绿假单胞菌性肺炎的疗效观察[J].安徽医药,2020,24(7):1461-1464. |
| 芩连翘皮方对老年铜绿假单胞菌性肺炎的疗效观察 |
| Curative efficacy of Qinlian Qiaopi decoction on pneumonia caused by pseudomonas aeruginosa in the elderly |
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| DOI：10.3969/j.issn.1009?6469.2020.07.048 |
| 中文关键词: 肺炎，细菌性 老年人 头孢他啶 铜绿假单胞菌 芩连翘皮方 临床疗效 |
| 英文关键词: Pneumonia,bacterial Aged Ceftazidime Pseudomonas aeruginosa Qinlian Qiaopi decoction Clinical curative efficacy |
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| 中文摘要: |
| 目的观察芩连翘皮方治疗老年人铜绿假单胞菌性肺炎病人的临床疗效及其对血清 C反应蛋白( CRP)和血清淀粉样蛋白 A(SAA)的影响。方法选取 2018年 1月至 2019年 1月唐山市中医医院收治的 94例老年铜绿假单胞菌性肺炎病人，采用随机数字表法按病人就诊顺序由小到大编号，分为观察组和对照组各 47例。对照组病人给予头孢他啶治疗，观察组在对照组基础上加用芩连翘皮方煎服。观察两组病人临床症状改善时间、临床综合疗效及细菌学疗效的差异以及治疗前后血清 CRP和 SAA水平的变化。结果治疗后观察组退热时间( 2.15±0.61)d、止咳时间( 4.56±0.64)d及咳痰消失时间( 5.99±0.97)d均显著短于对照组［(2.90±0.51)、(5.41±0.94)、(7.04±1.16)d］(P＜0.05)临床综合疗效、细菌学疗效均优于对照组( P＜0.05)。治疗后两组病人血清 CRP［观察组( 9.58±2.83)比( 27.12±5.87)mg/L、对照，组( 11.82±2.90)比( 26.74±8.15)mg/L］和 SAA［观察组( 8.91±2.89)比( 14.05±2.43)mg/L、对照组( 10.87±3.17)比( 13.67±2.53)mg/L］水平均较治疗前明显降低( P＜0.05)，且观察组［CRP(17.54±6.22)比( 14.92±8.14)mg/L、SAA(5.14±1.93)比( 2.80±1.50)mg/L］优于对照组。结论采用芩连翘皮方治疗老年人铜绿假单胞菌性肺炎病人疗效确切，能显著降低血清 CRP和 SAA水平。 |
| 英文摘要: |
| Objective To observe clinical curative efficacy of Qinlian Qiaopi Decoction on pneumonia caused by pseudomonas aeru? ginosa in the elderly and the influence on serum c?reaction protein(CRP)and serum amyloid A(SAA).Methods A total of 94 el? derly patientswith pseudomonas aeruginosa pneumonia admitted to Chinese Medicine Hospital of Tangshan from January2018 to Jan?uary2019 were selected and randomly divided into control group and treatment group，with 47 cases in each group.The control group was treated with ceftazidime，and the treatment group was treated with Qinlian Qiaopi Decoction on the basis of the control group.The differences of the improvement time of clinicalsymptoms，comprehensive curative efficacy and bacteriological efficacy were compared between the two groups，and the changes of serum CRP and SAA were compared before and after treatment.Results After treatment， times of defervescence(2.15±0.61)d，cough relief(4.56±0.64)d and expectoration disappearance(5.99±0.97)d in the treatment group were significantly shorter than those in the control group［(2.90±0.51)，(5.41±0.94)，(7.04±1.16)d］(P＜0.05).After treatment，the treatment group was better than the control group in comprehensive curative efficacy and bacteriological efficacy(P＜0.05).The lev? els of serum CPR［treatment group(9.58±2.83)vs.(27.12±5.87)mg/L，control group(11.82±2.90)vs.(26.74±8.15)mg/L］and SAA［treatment group(8.91±2.89)vs.(14.05±2.43)mg/L，control group(10.87±3.17)vs.(13.67±2.53)mg/L］were all induced significantly in the two groups than those before treatment(P＜0.05)，and these indicators in the treatment group［CRP(17.54±6.22)vs.(14.92±8.14)mg/L，SAA(5.14±1.93)vs.(2.80±1.50)mg/L］were superior to those in control group.Conclusion Qinlian Qiaopi Decoction shows definite curative efficacy on pseudomonas aeruginosa pneumonia in the elderly and reduces the levels of serum CPR and SAA. |
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