| 孙婷,乐娟,李艳.糖尿病合并高血压病人血小板参数的变化及临床意义[J].安徽医药,2020,24(8):1592-1595. |
| 糖尿病合并高血压病人血小板参数的变化及临床意义 |
| Changes and clinical significance of platelet parameters in patients with diabetes mellitus complicated with hypertension |
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| DOI：10.3969/j.issn.1009?6469.2020.08.029 |
| 中文关键词: 血小板/病理学 糖尿病 高血压 血小板参数 |
| 英文关键词: Blood platelets/pathology Diabetes mellitus Hypertension Platelet parameters |
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| 中文摘要: |
| 目的研究血小板参数在糖尿病(DM)及 DM合并高血压(HBP)病人中的变化及临床意义。方法收集 2018年 10月至 2019年 8月在武汉大学人民医院确诊为 2型糖尿病(T2DM)的病人 113例，将其作为 DM组； T2DM合并 HBP病人 157例，作为 DM合并 HBP组，并按照血压水平将其分为 HBPⅠ、Ⅱ、Ⅲ级三个亚组；检测并分析两组的空腹血糖(FPG)、糖化血红蛋白(HbA1c)、血小板计数(PLT)、血小板压积(PCT)、平均血小板容积(MPV)、血小板分布宽度(PDW)及大血小板比率(P?LCR)以及通过受试者工作特征(ROC)曲线比较 PLT、MPV、PDW、P?LCR、HbA1c对 DM合并 HBP的诊断价值；并探究 DM合并不同，严重程度 HBP病人以上指标的变化趋势。结果 DM合并 HBP组的 HbA1c［8.90(7.33，10.90)%比 8.70(6.68，10.48)%］、 PLT［222.00(191.50，268.00)109/L比 206.00(179.50，236.50)109/L］、 MPV［11.10(10.45，11.60)fl比 10.20(9.85，10.60)fl］、 PDW［(13.50±2.27)fl比(11.43±1.04)fl］、 P?LCR［(33.92±7.46)%比(25.94±4.49)%］的水平明显高于 DM组，且差异有统计学意义(P＜0.05)。随着 HBP严重程度的升高， FPG、MPV、PDW、P?LCR的水平升高，呈明显的上升趋势。 P?LCR的 ROC曲线下面积(AUC)为 0.812，大于 PLT(AUC为 0.618)，MPV(AUC为 0.805)、 PDW(AUC为 0.799)和 HbA1c(AUC为 0.578)对 DM合并 HBP的诊断价值最大。结论血小板参数与 DM合并 HBP的发生关系密切，对于诊断评估 DM合并 HBP有一定的价值。， |
| 英文摘要: |
| Objective To study the changes and clinical significance of platelet parameters in diabetesmellitus(DM)and DM pa? tients with hypertension(HBP).Methods A total of 113 patients with type 2 diabetes mellitus(T2DM)at the Renmin Hospital of Wuhan University from October 2018 to August 2019 were enrolled as the DM group，while 157 patients with T2DM combined withHBP were included in the DM combined with HBP group.And according to the level of blood pressure，patients with DM and HBP will be assigned into HBPⅠ，Ⅱ，Ⅲthree sub groups.Fasting blood glucose(FPG)， glycosylated hemoglobin(HbA1c)，platelet count(PLT)platelet volume(PCT)，mean platelet volume(MPV)，platelet distribution width(PDW)and large platelet ratio(P? LCR)weremea，sured and analyzed in the two groups，and the diagnostic values of PLT，MPV，PDW，P?LCR and HbA1c for DM combined with HBP were compared via the receiver operating characteristic(ROC)analysis.And the changes of the above indexesin patients with DM complicated with different severity of HBP were investigated. Results The levels of HbA1c［8.90(7.33，10.90)% vs. 8.70(6.68，10.48)%］，PLT［222.00(191.50，268.00)109/L vs. 206.00(179.50，236.50)109/L］MPV［11.10(10.45，11.60)fl vs. 10.20(9.85，10.60)fl］，PDW［(13.50±2.27)fl vs.(11.43±1.04)fl］and P?LCR［(33.92±7.46)% vs25.94±4.49)%］in the DM group with HBP were significantly higher than those in the DM group，and the difference was statistically significant(P＜0.05).With the increase of the severity of HBP，the level of FPG，MPV，PDW，P?LCR increased，showing a marked upward trend. The area under the curve(AUC)of P?LCR was 0.812，which was greater than 0.618 of PLT，0.805 of MPV，0.799 of PDW and 0.578 of HbA1c，the P?LCR had maximal diagnostic value for DM with HBP.Conclusion Platelet parameters is closely related to the occurrence of DM combined with HBP，which is valuable for the diagnosis and evaluation of DM combined with HBP. |
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