| 张远恒,陈绪江.复方丹参滴丸联合替罗非班改善经皮冠状动脉介入术后冠状动脉慢血流及心肌局部微循环障碍62例效果分析[J].安徽医药,2020,24(8):1639-1642. |
| 复方丹参滴丸联合替罗非班改善经皮冠状动脉介入术后冠状动脉慢血流及心肌局部微循环障碍62例效果分析 |
| Effect of compound danshen dripping pills combined with tirofiban in improving coronary slow flow and microcirculation after elective PCI for coronary heart disease |
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| DOI：10.3969/j.issn.1009?6469.2020.08.042 |
| 中文关键词: 冠心病 无复流现象 慢血流 复方丹参滴丸 替罗非班 微循环 |
| 英文关键词: Coronary heart disease No?reflow phenomenon Coronary slow flow Compound danshen dripping pill Tirofiban Microcirculation |
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| 目的探究复方丹参滴丸联合替罗非班改善冠心病经皮冠状动脉介入(PCI)择期治疗术后冠状动脉慢血流(CSF)及心肌局部微循环障碍的效果。方法选取 2017年 1月至 2018年 12月武汉市第三医院行 PCI择期治疗的冠心病病人 124例，采用随机数字表法分为对照组和观察组，每组 62例，对照组采用替罗非班治疗，观察组采用复方丹参滴丸联合替罗非班治疗，评估两组病人的术后近期及远期疗效，同时评价病人的心肌微循环灌注情况。结果观察组术后心绞痛发作次数(2.09±0.44)次，对照组(4.58±0.84)次，观察组明显低于对照组(P＜0.05)，同时观察组肌钙蛋白(I cTnI)［(0.17±0.03)比(0.56±0.12)U/L］肌酸激酶(CK?MB)［(30.48±4.82)比(56.34±5.59)μg/L］和丙二醛(MDA)［(6.04±0.55)比(8.68±0.77)μmol/L］水平与对照组相比明、显降低(P＜0.05)。且观察组与对照组心肌梗死溶栓治疗(TIMI)分级、治疗后校正 TIMI帧数(17.75±5.65)比(26.38±6.34)和中医心血瘀阻证证候积分分级均差异有统计学意义(P＜0.05)。此外观察组治疗过程中冠状动脉血流储备(CFR)上升明显(P＜0.05)。结论复方丹参滴丸联合替罗非班进可明显改善冠心病 PCI择期治疗术后的 CSF现象，改善病人冠脉和心肌微循环灌注。 |
| 英文摘要: |
| Objective To explore the clinical effect of compound danshen dripping pills combined with tirofiban in improving coro? nary slow flow(CSF)and microcirculation after elective transluminal percutaneous coronary intervention(PCI)for coronary heart disease.Methods A total of 124 patients with coronary heart disease undergoing elective PCI treatment in The Third Hospital ofWuhan form January 2017 to December 2018 were randomly assigned into control group(n＝62)and observation group(n＝62). The control group was treated with tirofiban，while the observation group adopted compound danshen dripping pills combined withtirofiban.The short?term and long?term efficacies of the two groups were evaluated postoperatively，and the myocardial microcircula? tory perfusion was also evaluated. Results The number of angina attacks was significantly reduced in the observation group［(2.09±0.44)vs.(4.58±0.84)P＜0.05］and the levels of cardiac troponin(cTnI)［(0.17±0.03)vs.(0.56±0.12)U/L］creatine ki? nase?MB(CK?MB)［(30.48±4.8，2)vs.(56，.34±5.59)μg/L］and malondialdehyde(MDA)［(6.04±0.55)vs.(8.68±0.77)，μmol/L］ were significantly decreased in the observation group when compared with the control group(P＜0.05).Meanwhile，there were sig? nificant differences between the two groups in thrombolysis in myocardial infarction(TIMI)grading，corrected TIMI frame［(17.75±5.65)vs.(26.38±6.34)］counted and integral stasis syndrome grading of traditional Chinese medicine blood stasis syndrome(P＜0.05).In addition，coronary flow reserve(CFR)increased significantly during the treatment in the observation group(P＜0.05). Conclusion The compound danshen dripping pills combined with Tirofiban could enhance the CSF after elective PCI for coronary heart disease，and improve coronary and myocardial microcirculation perfusion. |
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