| 文丽,杨小燕,张桂丽,等.基质金属蛋白酶9和凝血酶敏感蛋白1在亚临床甲状腺功能减退症稽留流产病人绒毛和蜕膜组织中表达的意义[J].安徽医药,2020,24(9):1760-1763. |
| 基质金属蛋白酶9和凝血酶敏感蛋白1在亚临床甲状腺功能减退症稽留流产病人绒毛和蜕膜组织中表达的意义 |
| Expression significance of MMP-9 and TSP-1 in chorion and decidua tissue of patients with subclinical hypothyroidism and missed abortion |
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| DOI：10.3969/j.issn.1009-6469.2020.09.016 |
| 中文关键词: 流产，稽留 甲状腺功能减退症 基质金属蛋白酶 9 凝血酶敏感蛋白 1 |
| 英文关键词: Abortion,missed Hypothyroidism Matrix metalloproteinase 9 Thrombospondin 1 |
| 基金项目:深圳市龙华区科技计划医疗卫生项目( 1030240) |
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| 中文摘要: |
| 目的探讨基质金属蛋白酶 9(MMP-9)和凝血酶敏感蛋白 1(TSP-1)在亚临床甲状腺功能减退症( SCH)稽留流产病人绒毛和蜕膜组织中表达的意义。方法选择 2017年 9月至 2018年 6月在深圳市龙华区人民医院确诊的 SCH稽留流产病人 25例，收集同期在该院就诊的正常妊娠并自愿行人工流产的 25例 SCH早孕病人作为对照。分析病人的一般资料；采用免疫组织化学 SP法检测绒毛和蜕膜组织中 MMP-9和 TSP-1的表达；采用受试者工作特征曲线( ROC)分析 MMP-9和 TSP-1对 SCH稽留流产病人的诊断价值，曲线下面积( AUC)表示预测价值。结果与 SCH早孕组相比， SCH稽留流产组病人绒毛和蜕膜组织中 MMP-9的表达水平明显下调［( 149.69±17.46)比( 180.36±20.58)t＝5.682，P＜0.001；(128.27±16.40)比( 154.72±17.43)t＝5.526，P＜0.001］， TSP-1的表达水平明显上调［( 152.71±18.83(127.76±15.62)， t＝5.099，P＜0.001；(160.25±17.44)比，)比,(138.54±14.78)t＝4.748，P＜0.001］；绒毛组织中 MMP-9、TSP-1以及 MMP-9联合 TSP-1预测 SCH病人稽留流产的 AUC依次为 0.824、0.794和 02，MMP-9联合 TSP-1预测 SCH病人稽留流产的 AUC明显高于 MMP-9或者 TSP-1单独检测( P＜0.05)；蜕膜组织中 MMP-9、TSP-1以及 MMP-9联合 TSP-1预测 SCH病人稽留流产的 AUC依次为 0.814、0.806和 0.915，MMP-9联合 TSP-1预测 SCH病人稽留流产的 AUC明显高于 MMP-9或者 TSP-1单独检测( P＜0.05)。结论绒毛和蜕膜组织中 MMP-9联合 TSP-1检.91，测对 SCH早孕病人稽留流产具有较高的诊断价值。 |
| 英文摘要: |
| Objective To explore expression significance of matrix metalloproteinase 9(MMP-9)and thrombospondin 1(TSP-1) in chorion and decidua tissue of missed abortion patients with subclinical hypothyroidism(SCH).Methods A total of 25 missed abortion patients with SCH who were diagnosed in Longhua District People’s Hospital from September 2017 to June 2018 were en-rolled.25 early pregnancy SCH patients who had normal pregnancy and voluntarily undergone artificial abortion were enrolled ascontrol group during the same period.The general data of patients were analyzed.The expression of MMP-9 and TSP-1 in chorionand decidua tissues was detected by immunohistochemical SP method.The diagnostic value of MMP-9 and TSP-1 for patients withSCH and missed abortion was analyzed by receiver operating characteristic curve(ROC)，and the and the area under the curve(AUC)represented predicted value.Results Compared with SCH early pregnancy group，the expression level of MMP-9 in chorion and decidua tissues of SCH and missed abortion group was significantly down-regulated［(149.69±17.46)vs.(180.36±20.58)，t＝5.682，P＜0.001；(128.27±16.40)vs.(154.72±17.43)t＝5.526，P＜0.001］while expression level of TSP-1 was significantly up-regulated［( 152.71±18.83)vs.(127.76±15.62)，t＝5.09，9，P＜0.001；(160.25，±17.44)vs.(138.54±14.78)，t＝4.748，P＜0.001］. AUC of MMP-9，TSP-1 and MMP-9 combined with TSP-1 in chorion tissue for predicting missed abortion of SCH patients were 0.824，0.794 and 0.912，respectively.AUC of MMP-9 combined with TSP-1 predicting missed abortion in SCH patients was signifi-cantly higher than that of MMP-9 or TSP-1 alone(P＜0.05).AUC of MMP-9，TSP-1 and MMP-9 combined with TSP-1 in decidua tis- sue for predicting missed abortion of SCH patients were 0.814，0.806 and 0.915，respectively.AUC of MMP-9 combined with TSP-1for predicting missed abortion in SCH patients was significantly higher than that of MMP-9 or TSP-1 alone(P＜0.05).Conclusion MMP-9 combined with TSP-1 in chorion and decidua tissues is of higher diagnostic value for missed abortion in SCH patients withearly pregnancy. |
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