| 郭祺,杨保仲,王辉,等.硬膜外分娩镇痛对新生儿脐血低氧诱导因子?1α含量的影响[J].安徽医药,2020,24(10):1986-1989. |
| 硬膜外分娩镇痛对新生儿脐血低氧诱导因子?1α含量的影响 |
| Effect of epidural anesthesia for labor analgesia on the level of hypoxia inducible factor?1α in umbilical cord blood |
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| DOI：10.3969/j.issn.1009?6469.2020.10.017 |
| 中文关键词: 镇痛，产科 镇痛，硬膜外 镇痛，病人控制 缺氧诱导因子 1，α亚基 脐动脉 超声检查，多普勒，彩色 |
| 英文关键词: Analgesia,obstetrical Analgesia,epidural Analgesia,patient?controlled Hypoxia?inducible factor 1,alpha sub? unit Umbilical arteries Ultrasonography,doppler,color |
| 基金项目:晋中市科技重点研发计划项目(Y173001) |
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| 中文摘要: |
| 目的评价硬膜外分娩镇痛对新生儿脐动脉血低氧诱导因子 ?1α(HIF?1α)含量的影响。方法选择 2018年 8月至 2019年 2月晋中市妇幼保健院健康单胎初产妇 64例，依据自愿接受硬膜外分娩镇痛原则分为镇痛组 30例，对照组 34例。镇痛组:采用自控硬膜外镇痛，待宫口开至 3 cm时，于 L2?3间隙行硬膜外穿刺，置入硬膜外导管并连接镇痛泵。对照组:自愿放弃镇痛措施，按正常自然分娩程序处理。记录两组产妇的镇痛效果(采用 Mulleetr镇痛强度评分法)、不同产程阶段脐动脉血流 S/D值、新生儿 Apgar评分、脐动脉血气；采用 ELISA法测定脐动脉中 HIF?1α的含量。结果镇痛组 Mulleetr评分 ≤2分所占比例(80.00%)明显高于对照组(29.41%)差异有统计学意义(χ2＝16.379，P＜0.01)；镇痛组 HIF?1α为(14.34±0.32)ng/L与对照组的(14.52±0.41)ng/L比较，差异无统计学，意义(t=1.877，P=0.065)；两组脐动脉血流 S/D值不同产程阶段组间比较差异无统计学意义(P＞0.05)；两组新生儿 Apgar评分、脐动脉血气结果分析比较，差异无统计学意义(P＞0.05)。结论硬膜外分娩镇痛不影响新生儿脐动脉血 HIF?1α含量，是一种安全有效的镇痛方法。 |
| 英文摘要: |
| Objective To evaluate the effect of epidural labor analgesia on hypoxic?inducible factor?1α(HIF?1α)content in neona? tal umbilical arterial blood.Methods Sixty?four healthy singleton primiparas inWomen Health Center of Jinzhong from August2018 to February 2019 were selected.According to the principle of voluntary epidural labor analgesia，30 patients in the analgesic group(E)and 34 patients in the control group(C).Group E:When the cervix dilation was opened to 3 cm，epidural puncture was performed in the L2?3 intervertebral space，and an epidural catheter was placed and connected to an analgesia pump.Group C:Volun? tary abandonment measures were taken and treated according to normal natural delivery procedures.The analgesic effect of the twogroups of women(using the Mulleetr analgesia intensity score)，the umbilical arterial blood flow S/D value at different stages of la? bor，the neonatal Apgar score，and the umbilical arterial blood gas were measured.ELISA method was used to determine the level ofHIF?1α in the umbilical artery.Results The proportion of mulleetr score ≤ 2 in the analgesia group(80.00%)was significantly higher than that in the control group(29.41%)，andthe difference was statistically significant(χ2=16.379，P＜0.01).The HIF?1α in the analgesia group was(14.34±0.32)ng/L，which was not significantly different from that in the control group［(14.52±0.41)ng/L］(t=1.877，P=0.065).There was no significant difference in the S/D values of the umbilical arterial blood flow between the two groups(P＞0.01).There were no significant differences in Apgar score，arterial blood gas results(P＞0.01).Conclusion Epidurallabor analgesia does not affect the content of HIF?1α in neonatal umbilical arterial blood，which is a safe and effective analgesic method. |
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