| 张晶晶,方庆凤.神经系统脱髓鞘性疾病抗氧化物质的变化及其意义[J].安徽医药,2020,24(11):2184-2188. |
| 神经系统脱髓鞘性疾病抗氧化物质的变化及其意义 |
| Changes of antioxidant substances in demyelinating diseases of nervous system and its nursing significance |
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| DOI：10.3969/j.issn.1009?6469.2020.11.017 |
| 中文关键词: 脱髓鞘疾病 格林 ?巴利综合征 胆红素 尿酸 白蛋白 |
| 英文关键词: Demyelinating diseases Guillain?Barre syndrome Bilirubin Uric acid Albumin Demyelination |
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| 中文摘要: |
| 目的观察血清胆红素(BIL)、尿酸(UA)、白蛋白(ALB)等抗氧化物质在神经系统脱髓鞘性疾病，如多发性硬化(MS)、视神经脊髓炎(NMO)、急性播散性脑脊髓炎(ADEM)及吉兰 ?巴雷综合征(GBS)中的变化，探讨抗氧化物质与脱髓鞘性疾病之间的关系。方法选取 2015年 1月至 2018年 12月在安徽省立医院住院的神经系统脱髓鞘疾病病人 251例，中枢神经系统脱髓鞘性疾病病人 146例，其中 MS组 95例， NMO组 31例， ADEM组 20例，周围神经系统脱髓鞘性疾病 GBS病人 105例；另外选取来自健康体检 175例作为健康对照组。采集空腹＞ 8h的血液，采用酶定量法测定血清 BIL、UA及 ALB值，考虑到性别因素对于结果的影响，我们将各组分为男女两组分别进行比较。结果 MS组(9.9±3.4)μm/L、NMO组(9.4±2.7)μm/L及 GBS组(10.7±4.4)μm/L无论男女血清总胆红素水平均低于健康对照组(12.5±4.7)μm/L，且 IBIL及 TBIL差异有统计学意义， MS组［UA(225±77)μm/L，ALB(39.5±4.3)g/L］NMO组［UA(198±91)μm/L，ALB(36.7±3.7)g/L］、 ADEM组［UA(206±77)μm/L，ALB(35.2±4.0)g/L］及 GBS组［UA(259±92)μm/L，ALB(40.0±4.4)g/L］无论男女血清中 UA和 ALB水平均显著低于健康对照组［UA(303±93)μm/L，ALB(42.1±3.3)g/L］。结论血清 BIL、UA及 ALB等抗氧化物质在神经系统脱髓鞘性疾病中发挥了重要的保护性作用，临床工作中或许可以通过补充外源性抗氧化物质或其前体来防止疾病的发生发展。 |
| 英文摘要: |
| Objective Observe anti?oxidation substances such as serum bilirubin(BIL)，uric acid(UA)and albumin(ALB)in de? myelinating diseases of the nervous system，such as multiple sclerosis(MS)and optic neuromyelitis(NMO).Changes in acute dis? seminated encephalomyelitis(ADEM)and Guillain?Barré syndrome(GBS)explore the relationship between antioxidants and demy? elinating diseases.Methods A total of 141 patients with central nervous system demyelinating diseases were enrolled，including90 patients in the MS group，31 in the NMO group，20 in the ADEM group，105 patients with peripheral nervous system demyelinat? ing disease GBS，and 175 from the health checkup as a normal control.The blood of the fasting＞8 hours was collected，and the se? rum BIL，UA and ALB values were determined by enzyme quantitative method.Considering the influence of gender factors on the re? sults，we divided the components into male and female groups.Results The serum bilirubin levels in MS(9.9±3.4)μm/L，NMO(9.4±2.7)μm/L and GBS(10.7±4.4)μm/L groups were lower than those in the normal control group(12.5±4.7)μm/L，and the differ? ences in IBIL and TBIL were statistically significant.The serum BIL level in the ADEM group was slightly higher than that in thenormal control group，and in the male group.The DBIL difference was statistically significant.The UA and ALB levels in the serumof males and females in MS group［UA(225±77)μm/L，ALB(39.5±4.3)g/L］，NMO group［UA(198±91)μm/L，ALB(36.7±3.7)g/L］， ADEM group［UA(206±77)μm/L，ALB(35.2±4.0)g/L］and GBS group［UA(259±92)μm/L，ALB(40.0±4.4)g/L］were significantly lower than those in normal control group［UA(303±93)μm/L，ALB(42.1±3.3)g/L］.Conclusion Antioxidant substances such as serum BIL，UA and ALB play an important protective role in demyelinating diseases of the nervous system.It maybe possible to prevent the occurrence and development of diseases by supplementing exogenous antioxidants ortheir precursors in clinical work. |
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