| 李莉,马金荣,潘红梅,等.中药内服外敷辅助秋水仙碱治疗急性痛风性关节炎 60例[J].安徽医药,2020,24(11):2276-2279. |
| 中药内服外敷辅助秋水仙碱治疗急性痛风性关节炎 60例 |
| Treatment of 60 cases of acute gouty arthritis with chinese medicine oral and external application assisted by colchicine |
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| DOI：10.3969/j.issn.1009?6469.2020.11.041 |
| 中文关键词: 关节炎，痛风性/中药疗法 中药内服外敷 秋水仙碱 视觉模拟疼痛评分 尿酸 血沉 |
| 英文关键词: Arthritis,gouty/drug therapy(TCD) Oral and external application of traditional Chinese medicine Colchicine Vi? sual analogue pain score Uric acid Erythrocyte sedimentation rate |
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| 中文摘要: |
| 目的探讨中药内服外敷辅助治疗急性痛风性关节炎的临床疗效及对视觉模拟疼痛(VAS)评分、血尿酸(BUA)及血沉(ESR)的影响。方法选取 2017年 3月至 2018年 6月河北省沧州中西医结合医院收治的急性痛风性关节炎病人 120例，按随机数字表法分为对照组(60例)与观察组(60例)。对照组给予秋水仙碱片治疗，观察组在对照组的基础上联合中药内服外敷辅助治疗。比较两组治疗前后的 BUA、ESR、肝肾功能指标丙氨酸氨基转移酶(ALT)与血肌酐(Scr)水平变化， VAS评分和临床症状积分，观察其临床疗效和不良反应。结果观察组治疗有效率 96.67％高于对照组 81.67％(P＜0.05)；两组治疗前 BUA、 ESR、ALT、Scr比较，差异无统计学意义(P＞0.05)两组治疗后 BUA、ESR、Scr组内比较均有好转，且观察组的 BUA［(423.17± 9.02)umol/L比(510.57±9.76)umol/L］和 ESR［(38.49，±1.27)mm/h比(46.31±1.18)mm/h］、 Scr［(80.96±13.19)umol/L比(90.92± 19.73)umol/L］水平均优于对照组(P＜0.05)；两组治疗前 VAS、临床症状积分比较，差异无统计学意义(P＞0.05)；两组治疗后 VAS、临床症状积分较治疗前均有改善，且观察组 VAS［(2.02±1.07)分比(3.11±1.15)分］、临床症状积分［(7.02±2.69)分比(9.62±2.73)分］均低于对照组(P＜0.05)；对照组与观察组不良反应发生率比较(6.67％比 8.33％)，差异无统计学意义(P＞0.05)。结论中药内服外敷辅助治疗急性痛风性关节炎的临床疗效确切，有效改善相关临床症状及血沉、尿酸等水平，具有较高安全性，值得推广。 |
| 英文摘要: |
| Objective To investigate the Clinical effect of oral andexternal application of traditional Chinese medicine on acute gouty arthritis and its influence on visual analog?pain score(VAS)， blood uric acid(BUA) and erythrocyte sedimentation rate(ESR).Methods From March 2017 to June 2018，120 patients with acute gouty arthritis were randomly divided into control group(60 cases)and observation group(60 cases)by random number table.The cases in the control group were treated with colchicine tablets，while the cases in the observation group were treated with Oral and external application of traditional Chinese medicine onthe basis of the control group.The changes of BUA，ESR，ALT and Scr levels，VAS scores and clinical symptom scores before and after treatment were compared and analyzed，and the clinical efficacy and adverse reactions were observed and compared between two groups.Results The effective rate of the observation group was higher than that in the control group(96.67% vs. 81.67%)(P＜0.05).There was no significant difference in the levels of BUA，ESR，ALT and Scr between the two groups before treatment(P＞ 0.05).Aftertreatment，the BUA，ESR and Scr levels were improved，and the BUA［(423.17±9.02)umol/L vs.(510.57±9.76)umol/L］， ESR［(38.49±1.27)mm/h vs.(46.31±1.18)mm/h］and Scr levels［(80.96±13.19)umol/L vs.(90.92±19.73)umol/L］in the observa? tion group were better than those in the control group(P＜0.05).There was no significant difference in the VAS and clinical symp? tom scores before treatment between two groups(P＞0.05).After treatment，the VAS and clinical symptom scores of the two groups were significantly improved compared with those before treatment，and the VAS［(2.02±1.07)vs.(3.11±1.15)］ and clinical symp? tom scores［(7.02±2.69)vs.(9.62±2.73)］of the observation group were lower than those in the control group(P＜0.05).The inci? dence of adverse reactions was not statistically different between two groups(6.67% vs. 8.33%)(P＞0.05).Conclusion Oral and external application of traditional Chinese medicine in the treatment of acute gouty arthritis has a definite clinical effect，which can effectively improve clinical symptoms，and the levels of erythrocyte sedimentation rate and uric acid.It has high safety and is worthy of promotion. |
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