| 闵自强,林启鹏,罗程,等.氢溴酸山莨菪碱肌内注射联合推拿治疗发作期梅尼埃病 79例临床观察[J].安徽医药,2020,24(12):2415-2418. |
| 氢溴酸山莨菪碱肌内注射联合推拿治疗发作期梅尼埃病 79例临床观察 |
| Clinical observation on treating 79 cases of acute Ménière disease with anisodamine hydrobromide intramuscular injection combined with manipulation |
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| DOI：10.3969/j.issn.1009?6469.2020.12.021 |
| 中文关键词: 梅尼埃病 推拿 山莨菪碱 耳鸣 眩晕 |
| 英文关键词: Ménière disease Manipulation Anisodamine Tinnitus Vertigo |
| 基金项目:四川省科技支撑计划项目(2016SZ0027) |
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| 中文摘要: |
| 目的探讨氢溴酸山莨菪碱注射液联合推拿治疗发作期梅尼埃病的有效性和安全性。方法将 2017年 8月至 2019年 5月武警四川省总队医院发作期梅尼埃病病人 158例按随机数字表法分为试验组和对照组，每组 79例。对照组给予氢溴酸山莨菪碱注射液，肌内注射，首日剂量 10毫克 /次， 1次/天，次日开始 20毫克 /次， 1次/天， 7d为 1个疗程，连续使用 2个疗程。试验组在对照组基础上，加用推拿。比较两组病人经治疗两周后的总有效率及头晕残障问卷(DHI)、耳鸣致残量表(THI)、耳闷视觉模拟评分(VAS)评分，以及不良反应。结果经治疗 2周后，试验组总有效率高于对照组，差异有统计学意义(93.67%比 82.28%，χ2＝6.939，P＝0.031)；试验组的 DHI、THI、VAS评分较对照组更低［DHI:(35.39±4.37)分比(38.25±8.58)分， t＝2.640， P＝0.009；THI:(37.54±7.37)分比(41.37±8.94)分， t＝2.938，P＝0.004；VAS:(5.46±1.89)分比(6.39±2.11)分， t＝2.918，P＝0.004］。在不良反应方面，试验组出现 5例潮红、口干，对照组出现 6例潮红、口干，均未经干预， 2～4h后自行消失，余未见不良反应，两组不良反应发生率差异无统计学意义(χ2＝0.098，P＝0.755)。结论推拿联合氢溴酸山莨菪碱注射液治疗发作期梅尼埃病较单用氢溴酸山莨菪碱注射液更为有效，安全性佳，无严重不良反应发生，可考虑作为临床治疗梅尼埃病的一种治疗方案。 |
| 英文摘要: |
| Objective To explore the efficacy and safety of manipulation combined with anisodamine hydrobromide injection in thetreatment of acute Ménière disease.Methods A total of 158 patients with Ménière diseasetreated in Armed Police Sichuan Provin?cial Corps Hospital from August 2017 to May 2019 were randomly assigned into the experimental group and the control group，with 79 cases in each group.The control group was given anisodamine hydrobromide injection，intramuscularly；the first?day dose was 10 mg/time，1 time/day，and the subsequent dose was 20 mg/time，1 time/day.A total of 7 days was a course of treatment，and 2 courses were used continuously.The experimental group received additionally manipulation on the basis of the therapy in the control group.The total effective rate and Dizziness Handicap Inventory(DHI)， Tinnitus Handicap Inventory(THI)， Visual Analogue Scale(VAS)scores，and adverse events were compared between the two groups after two weeks of treatment.Results After two?week treatment，the total effective rate of the experimental group was higher than that of the control group，and the difference was statisti? cally significant(93.67% vs. 82.28%，χ2＝6.939，P＝0.031).The DHI，THI and VAS scores of the experimental group were lower than those of the control group，and the difference was statistically significant［DHI:(35.39±4.37)vs.(38.25±8.58)t＝2.640，P＝ |
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