| 徐万洲,李迪,吴青,等.华裔中年女性每日总维生素 B12摄入量与焦虑症的关系[J].安徽医药,2020,24(12):2527-2531. |
| 华裔中年女性每日总维生素 B12摄入量与焦虑症的关系 |
| The relationship between daily total vitamin B12 intake and anxiety disorders in middle?aged Chinese women |
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| DOI：10.3969/j.issn.1009?6469.2020.12.049 |
| 中文关键词: 焦虑症 膳食调查 维生素 B12 危险因素 横断面研究 女性 亚裔美国人 |
| 英文关键词: Anxiety disorders Diet surveys Vitamin B12 Americans |
| 基金项目:国家临床重点专科建设项目资助(财社〔2010〕305号) |
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| 中文摘要: |
| 目的研究华裔中年女性每日维生素 B12(vitamin B12，VB12)摄入量与焦虑症的关系。方法本研究数据来自美国妇女健康研究(Study of Women’s Health Across the Nation，SWAN)。焦虑症通过参与者自评量表的方式评估，维生素 B(B1，B2， B3，B6，B9，B12)的每日摄入量由 1986年版饮食频率调查问卷推算， Fisher确切概率法比较组间率的差异， Mann?Whitney U比较两组变量通体均值的差异， logistic回归分析 VB12与焦虑症之间的关系，限制性三次样条分析两者的非线性关系。结果在纳入研究的 241例女性中， 10例(4.1%)患有焦虑症。焦虑组倾向有更高的脉搏和总胆固醇(P分别为 0.034，0.009)。焦虑组女性的每日总 VB12摄入量的中位数(下、上四分位数)为 1.78(1.01，2.03)μg/d，低于对照组的 2.34(1.47，3.27)μg/d(P＝0.027)。在焦虑组中，符合 VB12每日膳食营养素推荐供给量(RDA)标准的女性少于对照组(P＝0.023)。总 VB12摄入量与焦虑症呈负相关关系，且低水平 VB12摄入量人群发生焦虑症的风险更高(OR＝10.25，95%CI:1.28～82.22)。在调节了年龄后，这种关系依然存在。在充分调整潜在混杂因素年龄、脉搏和总胆固醇后，总 VB12摄入量仍然与焦虑症负相关(OR＝0.36，95%CI:0.15～0.84)。此外，低水平 VB12摄入量的焦虑症风险更高(OR＝19.42，95%CI:2.08～180.98)。符合 VB12摄入量 RDA标准的人群发生焦虑症的风险低于 VB12摄入量不足人群(OR＝0.12，95%CI:0.02～0.98)。在调整协变量后，这种关系依然存在(OR＝0.08，95%CI:0.01～0.66)。限制性三次样条表明，随着 VB12摄入量的增高，焦虑症发生风险先处于平台期，随后逐渐下降。结论总 VB12摄入量与焦虑症呈负相关关系。由于是横断面研究，因此 VB12可能是焦虑症的保护因素；而低水平 VB12也可能是焦虑症所致。 |
| 英文摘要: |
| Objective To study the relationship between daily vitamin B12 intake and anxiety disorders in middle?aged Chinese women.Methods Data used in present study were from Study of Women’s Health Across the Nation(SWAN).Anxiety disorders were assessed by participant self?rating scale.Daily intake amounts of vitamin B(B1，B2，B3，B6，B9，B12)were calculated based on 1986 version of food?frequency questionnaire.Fisher precise probability method was used to compare the differences in inter?group rates.Mann?Whitney U was used to compare the difference in general means of variables between the two groups.The associa?tion of VB12 intake with anxiety was examined using logistic regression analysis and the non?lineal relationship was analyzed by re?stricted cubic splines.Results Of the 241 women included in the study，10(4.1%)suffered from anxiety.Pulse and total cholester? ol tended to be higher in anxiety group than the control group(P＝0.034，0.009).The median(lower quartile，upper quartile)of dai? ly intake of vitamin B12 in anxiety group was lower than that in control group［1.78(1.01，2.03)μg/d vs. 2.34(1.47，3.27)μg/d，P＝0.027］.In anxiety group，fewer women met the vitamin B12 recommended dietary allowance(RDA)standard than the control group(P＝0.023).There was a negative correlation of total vitamin B12 intake with anxiety disorders.People with lower vitaminB12 intake had a higher risk of developing anxiety disorder(OR＝10.25，95%CI:1.28?82.22).After ageadjustment，such relation? ship still existed.Negative correlation of total vitamin B12 intake with anxiety disorders still existed after the adjustment of potentialconfounding factors such as age，pulse and total cholesterol(OR＝0.36，95%CI:0.15?0.84).Besides，lower vitamin B12 intake was associated with a higher risk of anxiety disorders(OR＝19.42，95%CI:2.08?180.98).The risk of anxiety in people who met vitaminB12 intake RDA criteria was lower than that in people who had insufficient vitamin B12 intake(OR＝0.12，95%CI:0.02?0.98).Af? ter adjusting the covariates，such relationship still existed(OR＝0.08，95%CI:0.01?0.66).Restricted cubic splines showed that with the increase of vitamin B12 intake，the risk of developing anxiety disorders was in plateau stage at first，and then decreased gradual? ly.Conclusions Total vitamin B12 intake was negatively correlated with anxiety disorders.Due to the cross?sectional study，vitamin B12 may be a protective factor for anxiety disorders，and low levels of vitamin B12 may also be caused by anxiety disorders. |
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