| 傅兰勇,曾笑梅.依诺肝素钠预防高危产妇剖宫产术后静脉血栓形成疗效分析[J].安徽医药,2020,24(12):2532-2534. |
| 依诺肝素钠预防高危产妇剖宫产术后静脉血栓形成疗效分析 |
| Effect of enoxaparin sodium on preventing venous thrombosis in high?risk pregnant women after cesarean section |
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| DOI：10.3969/j.issn.1009?6469.2020.12.050 |
| 中文关键词: 依诺肝素 剖宫产术 手术后并发症 静脉血栓形成 妊娠，高危 |
| 英文关键词: Enoxaparin Cesarean section Postoperative complications Venous thrombosis Pregnancy,high?risk |
| 基金项目: |
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| 中文摘要: |
| 目的探析依诺肝素钠预防高危产妇剖宫产术后静脉血栓形成的临床疗效。方法选取 2017年 1月至 2018年 12月于宁德市医院住院，并予行子宫下段横切口剖宫产术终止妊娠的高危产妇 136例，抽签分为研究组与对照组，每组 68例。两组病人均指导其术后 6h后开始床上翻身，活动双下肢，术后第 1天辅助其适当下床活动。研究组在上述基础上于术后第 1天给予依诺肝素钠 4 000 U皮下注射，每天 1次，持续 7d。比较两组病人静脉血栓栓塞情况及凝血功能改变。结果两组病人年龄与孕周比较，差异无统计学意义(P＞0.05)。对照组有 10例(14.71%)病人静脉血栓形成，明显高于研究组(0例)(P＜0.05)。两组病人剖宫产术前凝血功能［D?二聚体、纤维蛋白原(FIB)、凝血酶原时间(PT)、活化部分凝血酶时间(APTT)］比较，差异无统计学意义(P＞0.05)。而术后第 5天复查，研究组病人 D?二聚体、 FIB显著下降， PT、APTT值明显上升；而对照组 D?二聚体、 FIB、PT、APTT值均有所上升。两组病人分别与各自术前比较，均差异有统计学意义(P＜0.05)。术后第 5天复查凝血功能，研究组病人 D?二聚体、 FIB明显低于对照组， PT、APTT均显著高于对照组，均差异有统计学意义(P＜0.05)。结论依诺肝素钠能有效地预防高危病人剖宫产术后静脉血栓形成，可在临床中应用推广，并为国内高危产妇抗凝治疗选择提供依据。 |
| 英文摘要: |
| Objective To explore the clinical effect of enoxaparin sodium in preventing venous thrombosis in high?risk pregnantwomen after cesarean section.Methods A total of 136 high?risk pregnant women who were hospitalized in Ningde City Hospitalfrom January 2017 to December 2018 and underwent cesarean section of transverse incision at the lower section of uterus were se?lected and randomly assigned into study group and control group by drawing lots，with 68 cases in each group.Patients in bothgroups were instructed to start turning over in bed 6 h after surgery and to move their lower limbs.On the 1st day after surgery，theywere assisted to get out of bed properly.Additionally，the research group received 4 000 U of enoxaparin sodium subcutaneouslyonce daily for 7 days after the surgery.The venous thromboembolism and the change of coagulation function were compared betweenthe two groups.Results There were no significant differences in age and weeks of gestational between the two groups(P＞0.05). Venous thrombosis occurred in 10 patients(14.71%)in the control group，which was significantly higher than that in the study group(0 case)(P＜0.05).Comparison of coagulation function［D?dimer，fibrinogen(FIB)prothrombin time(PT)，activated par? tialthrombintime(APTT)］betweenthetwogroupsbeforecesareansectionshowednosta，tistically significant difference(P＞ |
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