| 王英娟,苏乐,贺巧峰,等.甲泼尼龙冲击疗法治疗小儿过敏性紫癜 50例临床疗效[J].安徽医药,2021,25(1):144-147. |
| 甲泼尼龙冲击疗法治疗小儿过敏性紫癜 50例临床疗效 |
| Methylprednisolone pulse therapy for allergic purpura in children: a report of 50 cases |
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| DOI：10.3969/j.issn.1009?6469.2021.01.036. |
| 中文关键词: 紫癜，过敏性 甲泼尼龙 白细胞介素 6 白细胞介素 10 肿瘤坏死因子 α 免疫球蛋白类 儿童 |
| 英文关键词: Purpura,schoenlein?henoch Methylprednisolone Interleukin?6 Interleukin?10 Tumor necrosis factor?al? pha Immunoglobulins Child |
| 基金项目:陕西省重点研发计划项目(2017SF?239) |
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| 中文摘要: |
| 目的探讨甲泼尼龙冲击疗法治疗小儿过敏性紫癜的临床效果及其对炎性因子的影响。方法选取 2018年 1月至 2019年 4月榆林市第一医院收治的小儿过敏性紫癜病人 100例，按随机数字表法分为对照组和观察组，每组 50例。对照组给予孟鲁司特钠治疗，观察组病人在对照组基础上给予甲泼尼龙。观察两组病人治疗后临床效果和不良反应，临床症状缓解时间，以及治疗前后血清白细胞介素 ?6(IL?6)白细胞介素 ?10(IL?10)肿瘤坏死因子 ?α(TNF?α)免疫球蛋白 A(IgA)免疫球蛋白 M(IgM)，免疫球蛋白 E(IgE)含量变化。结果，观察组临床总有效率(，96%)高于对照组(82%)，，不良反应发生率(4%)，低于对照组(22%)差异有统计学意义(P＜0.05)。观察组病人紫癜消退时间、关节疼痛改善时间、消化道症状改善时间分别为(7.74±1.26)、(3±1.13)、(3.72±1.12)d，对照组分别为(8.56±1.32)、(5.42±1.27)、(5.48±1.13)d，观察组均短于对照组，差异有统计学意义(P＜0.05)。观察组治疗后 IL?6、IL?10、TNF?α、IgA、IgM及 IgE水平分别为(23.71±7.14)、(40.73±9.91)、(47.72±7.14)、.24，(2.55±0.45)、(1.11±0.34)、(108.32±17.17)g/L，对照组分别为(27.44±7.22)、(53.31±16.24)、(62.17±7.24)、(3.54±0.43)、(1.28±0.33)、(48.32±17.17)g/L，观察组均低于对照组，差异有统计学意义(P＜0.05)。结论甲泼尼龙治疗小儿过敏性紫癜具有较好的临床治疗效果，可有效改善病人的临床症状，降低炎性因子水平，且不良反应率较低，值得临床应用。 |
| 英文摘要: |
| Objective To investigate the effect of methylprednisolone pulse therapy on inflammatory factors and clinical effectsin children with allergic purpura.Methods A total of 100 patients with pediatric allergic purpura admitted to First Hospital ofYulin from January 2018 to April 2019 were randomly divided into control group and observation group，with 50 cases in each group.Patients in control group were treated with montelukast sodium，while those in observation group were treated with methyl? prednisolone on the basis of montelukast sodium.The clinical effect，adverse reactions，the clinical symptom remission time，the se? rum levels of IgA，IgM，IgE，IL?6，IL?10 and TNF?α before and after treatment were observed in both groups.Results The total ef? fective rate of the observation group(96%)was significantly higher than that of the control group(82%)(P＜0.05)，while the ad? verse reaction incidence of the observation group(4%)was lower than that of the control group(22%)，the difference was statisti? cally significant(P＜0.05). The purpura regression time，joint pain improvement time，and gastrointestinal symptom improvement time were(7.74±1.26)，(3.24±1.13)(3.72±1.12)d，respectively，in the observation group，and(8.56±1.32)，(5.42±1.27)，(5.48±1.13)d in the control group，those in the observation group were significantly shorter than those in the control group(P＜0.05).The levels of serum IL?6，IL?10，TNF?α，IgA，IgM and IgE were(23.71±7.14)，(40.73±9.91)，(47.72±7.14)，(2.55±0.45)，(1.11±0.34)，(108.32±17.17)g/L in the observation group，and(27.44±7.22)，(53.31±16.24)，(62.17±7.24)，(3.54±0.43)，(1.28±0.33)，(48.32±17.17)g/L in the control group，those in the observation group were significantly lower than those in the control group(P＜0.05). Conclusion Methylprednisolone has a good clinical effect in the treatment of Henoch?Schonlein purpura in children，can effective? ly improve the clinical symptoms of patients，reduce the level of inflammatory factors，and the adverse reaction rate is low，which is worthy of clinical application. |
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