| 陈丽娟,李进东,吴晓丽,等.两性霉素 B脂质体联合伏立康唑治疗急性髓系白血病合并曲霉菌感染 21例疗效观察[J].安徽医药,2021,25(1):169-172. |
| 两性霉素 B脂质体联合伏立康唑治疗急性髓系白血病合并曲霉菌感染 21例疗效观察 |
| Observation of curative effect of amphotericin B liposome combined with voriconazole for acute myeloid leukemia with aspergillus infection of 21 patients |
| |
| DOI：10.3969/j.issn.1009?6469.2021.01.042. |
| 中文关键词: 白血病，髓系 曲霉菌病 两性霉素 B 伏立康唑 肾功能 |
| 英文关键词: Leukemia,myelogenous Aspergillosis Amphotericin B Voriconazole Renal function |
| 基金项目: |
|
| 摘要点击次数: 2866 |
| 全文下载次数: 1129 |
| 中文摘要: |
| 目的观察两性霉素 B脂质体联合伏立康唑治疗急性髓系白血病合并曲霉菌感染的疗效。方法选取泰州市人民医院 2018年 1—12月收治的急性髓系白血病合并曲霉菌感染 39例，按简单随机抽样法分为对照组(n＝18)和观察组(n＝21)。对照组采用单一的伏立康唑治疗，观察组采用两性霉素 B脂质体与伏立康唑联合治疗；两组在治疗前、治疗中及治疗后均复查肌酐、尿素水平。结果对照组治疗(15.72±9.06)d，治疗前后肌酐和尿素水平比较 P＞0.05；观察组治疗(17.90±11.06)d，疗前后肌酐(51.51±17.95)、(116.37±20.64)μmol/L和尿素水平(5.27±1.43)、(9.96±3.56)mmol/L比较 P＜0.01。观察组治疗有效治率为 90.47%高于对照组 61.11%(Z＝-2.045，P＜0.05)。结论两性霉素 B脂质体联合伏立康唑治疗急性髓系白血病合并曲霉菌感染病人的临床治疗效果明显优于单独使用伏立康唑，然而应注意控制剂量，监测肾功能。 |
| 英文摘要: |
| Objective To analyze the clinical efficacy of liposomal amphotericin B combined with voriconazole for acute myeloidleukemia with Aspergillus infection of 21 patients.Methods 39 patients from January to December 2018 with acute myeloid leuke?mia complicated with aspergillus infection admitted to the Department of Hematology from Taizhou People’s Hospital were select? ed，they were randomly divided into control group(n＝18)and observation group(n＝21).The control group was treated with vori? conazole alone，while the observation group was treated with liposomal amphotericin B combined with Voriconazole.The Creatinineand urea levels were reviewed before and after treatment in both groups. Results The control group had an average treatment(15.72±9.06)d，and there was no significant difference in creatinine and urea levels before and after treatment(P＞0.05)； the ob? servation group had an average treatment(17.90±11.06)d，and the creatinine levels before and after treatment were(51.51±17.95) μmol·L-1，(116.37±20.64)umol·L-1 respectively，and the urea levels were(5.27±1.43)mmol/L?1，(9.96±3.56)mmol/L?1 respectively， the difference was statistically significant(P＜0.01).The effective rate of the observation group(90.47%)was higher than that of the control group(61.11%)，and the difference was statistically significant(Z＝-2.045，P＜0.05).Conclusion Liposomal ampho?tericin B combined with voriconazole for acute myeloid leukemia patients with Aspergillus infection is significantly more effectivethan that of patients treated with voriconazole alone.However，attention should be paid to dose control and renal function monitoring. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
