| 王丽娜,赵瑞婧,刘美芳,等.结核感染 T细胞斑点试验检测外周血及胸腔积液对诊断结核性胸膜炎价值的 Meta分析[J].安徽医药,2021,25(2):213-217. |
| 结核感染 T细胞斑点试验检测外周血及胸腔积液对诊断结核性胸膜炎价值的 Meta分析 |
| Meta-analysis of the value of tuberculosis infection T cellspot testin detecting peripheral blood and pleural effusion in diagnosis of nuclear pleurisy |
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| DOI：10.3969/j.issn.1009-6469.2021.02.001. |
| 中文关键词: 结核，胸膜 酶联免疫斑点测定 结核感染 T细胞斑点试验 胸腔积液 外周血 |
| 英文关键词: Tuberculosis, pleural Enzyme-linked immunospot assay Tuberculous infection of T cells spot test Pleural effusion Peripheral blood |
| 基金项目:陕西省中医管理局中医药科研课题( JCMS062)；陕西省科学技术厅重点研发计划项目( 2019SF-020) |
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| 中文摘要: |
| 目的评估 T细胞酶联免疫斑点试验( tuberculous infection of T cells spot test，T-SPOT.Tb)检测外周血与胸腔积液诊断结核性胸膜炎的价值。方法计算机检索 Medline、PubMed、VIP、CNKI、和万方医学网等数据库，检索时间截至 2019年 11月，纳入对外周血与胸腔积液进行 T-SPOT.Tb检测的临床诊断性试验的研究。对所检索的文献进行筛选、资料提取及进行 Cochrane系统评价方法学质量评价后，采用 Stata15.0软件进行 Meta分析。结果共纳入 13个诊断性试验研究，合计 1 260例病人。研究结果显示:外周血和胸腔积液 T-SPOT.Tb检测的合并灵敏度为 0.87和 0.97，合并特异度为 0.82和 0.83，合并阳性似然比为 4.8和 5.5，合并阴性似然比为 0.16和 0.04，合并诊断价值比 DOR分别为 31和 132。SROC曲线显示: AUC分别为 0.90和0.98。结论针对结核性胸膜炎的诊断， T-SPOT.Tb检测胸腔积液的价值优于检测外周血。 |
| 英文摘要: |
| Objective To evaluate the value of tuberculous infection of T cells spot test (t-spot.tb) for peripheral blood and pleural effusion diagnosis of tuberculous pleurisy.Methods The databases of Medline,PubMed,VIP,CNKI, and Wanfang medical network weresearched by computer.The retrieval period was up to November 2019,and the study was included in the clinical diagnostic test of t-spot.Tb detection of peripheral blood and pleural effusion.After screening,data extraction and Cochrane systematic evaluation methodologyquality evaluation of the retrieved literatures, Meta-analysis was performed with Stata 15.0 software.Results A total of 13 diagnostic trial studies were included, with a total of 1 260 patients. The results showed that the combined sensitivity of t-spot.tb test in peripheralblood and pleural effusion was 0.87 and 0.97,the combined specificity was 0.82 and 0.83, the combined positive likelihood ratio was |
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