| 汤明,方春田,彭唯.新辅助化疗对 ⅠB～ⅡB期宫颈癌病灶内恶性生物学特征的影响[J].安徽医药,2021,25(2):317-320. |
| 新辅助化疗对 ⅠB～ⅡB期宫颈癌病灶内恶性生物学特征的影响 |
| Effects of neoadjuvant chemotherapy on malignant biological characteristics in ⅠB～ⅡB stage cervical cancer lesions |
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| DOI：10.3969/j.issn.1009-6469.2021.02.026. |
| 中文关键词: 宫颈肿瘤 化学疗法，辅助 增殖 侵袭 自噬 |
| 英文关键词: Uterine cervical neoplasms Chemotherapy, adjuvant Proliferation Invasion Autophagy |
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| 中文摘要: |
| 目的探讨新辅助化疗对 ⅠB～ⅡB期宫颈癌病灶内恶性生物学特征的影响。方法选取 2015年4月至 2018年 1月间在洪湖市人民医院接受治疗的 ⅠB～ⅡB期宫颈癌病人 157例，均接受术前新辅助化疗＋根治性手术治疗。留取新辅助化疗前后宫颈癌组织标本各 157份作为研究对象。对比新辅助化疗前后，宫颈癌组织中增殖、侵袭、自噬相关基因表达量的差异。结果新辅助化疗后，宫颈癌组织中增殖相关基因 FOXP3［(50.18±5.64)比(77.49±8.12)］、HOXA7［(59.26±7.18)比(86.34±9.73)］、USP22［(75.09±8.62)比(101.26±13.18)］、Sox2 mRNA［(67.91±8.65)比(95.42±11.83)］的表达量低于新辅助化疗前， TSLC1 mRNA的表达量高于新辅助化疗前［(125.48±14.19)比(90.72±9.82)］；侵袭相关基因 FAK［(69.33±8.51)比(102.17±14.58)］、MACC1［(71.09±8.56)比(93.22±10.81)］、 GRP94［( 65.88±9.21)比( 90.71±9.85)］、 PRPS2［( 89.07±9.23)比( 114.32±15.68)］、 TPX2 mRNA［( 71.71±8.38)比( 85.36±9.21)］的表达量低于新辅助化疗前；自噬相关基因 Beclin1［(131.75±15.59)比(106.38±14.32)］、LC3-B［(120.66±13.58)比(94.27±11.60)］、PI3KC3 mRNA［(100.64±12.38)比(85.48±9.02)］的表达量均高于新辅助化疗前。结论 ⅠB～ⅡB期宫颈癌病人在根治性手术前接受新辅助化疗，可进一步抑制癌细胞的增殖、侵袭活力并调节其自噬活性。 |
| 英文摘要: |
| Objective To investigate the effects of neoadjuvant chemotherapy on malignant biological characteristics in ⅠB-ⅡB stage cervical cancer lesions.Methods Totally 157 patients with ⅠB-ⅡB stage cervical cancer who were treated in The People'sHospital of Honghu between April 2015 and January 2018 were selected, and all of them underwent preoperative neoadjuvant chemotherapy plus radical operation.A hundred and fifty-seven cervical cancer tissue samples were collected before and after neoadjuvantchemotherapy respectively.The differences in the expression of genes related to proliferation, invasion and autophagy in cervical cancertissues were compared before and after neoadjuvant chemotherapy.Results After neoadjuvant chemotherapy, proliferation-related genes FOXP3 [(50.18±5.64)vs.(77.49±8.12)],HOXA7 [(59.26±7.18)vs.(86.34±9.73)],USP22 [(75.09±8.62)vs.(101.26±13.18)] and Sox2 mRNA [(67.91±8.65)vs.(95.42±11.83)] expressions in cervical cancer tissues were lower than those before neoadjuvant chemotherapywhereas TSLC1 mRNA expression was higher than that before neoadjuvant chemotherapy [(125.48±14.19)vs.(90.72±9.82)]. Invasion-related genes FAK [(69.33±8.51)vs. (102.17±14.58)], MACC1[(71.09±8.56)vs. (93.22±10.81)], GRP94 [(65.88±9.21)vs. (90.71±9.85)], PRPS2 [(89.07±9.23)vs.(114.32±15.68)],TPX2 mRNA [(71.71±8.38)vs.(85.36±9.21)] expressions were lower than those before neoadjuvant chemotherapy. Autophagy-related genes Beclin1 [(131.75±15.59)vs. (106.38±14.32)], LC3-B [(120.66±13.58)vs. (94.27±11.60)], PI3KC3 mRNA [(100.64±12.38) vs.(85.48±9.02)] expressions were higher than those before neoadjuvant chemotherapy.Conclusion Neoadjuvant chemotherapy before radical operation can further inhibit the proliferation and invasion activity of cancer cells and adjusttheir autophagy activity in patients with ⅠB-ⅡB stage cervical cancer. |
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