| 李小英.外涂 20％超分子水杨酸及口服盐酸米诺环素联合红蓝光治疗中重度痤疮 51例[J].安徽医药,2021,25(2):366-369. |
| 外涂 20％超分子水杨酸及口服盐酸米诺环素联合红蓝光治疗中重度痤疮 51例 |
| Clinical effect and adverse reaction of supermolecular salicylic acid in combination with oral minocycline and red blue light therapy in the treatment of patients with moderate to severe pressure acne |
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| DOI：10.3969/j.issn.1009-6469.2021.02.037. |
| 中文关键词: 寻常痤疮 盐酸米诺环素 超分子水杨酸 红蓝光治疗仪 临床疗效 |
| 英文关键词: Acne vulgaris Minocycline hydrochloride Supramolecular salicylic acid Red blue light therapeutic instrument Clinical effect |
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| 中文摘要: |
| 目的探讨外涂 20％超分子水杨酸及口服盐酸米诺环素联合红蓝光治疗仪治疗中重度痤疮的临床效果及不良反应，为中重度痤疮治疗提供更加安全有效的方法。方法选取 2016年 5月至 2019年 2月广西壮族自治区桂东人民医院收治的中重度痤疮病人 102例，采用随机数字表法分成观察组与对照组，每组 51例，对照组采取口服盐酸米诺环素 +红蓝光治疗仪治疗，观察组在对照组治疗方法的基础上加用 20％超分子水杨酸外涂治疗，对比两组临床疗效、治疗前后的痤疮综合分级系统(GAGS)评分以及不良反应发生情况。结果观察组治疗总有效率 90.20％，对照组为 72.55％，组间对比差异有统计学意义(P = 0.022)；治疗前观察组与对照组 GAGS评分差异无统计学意义［(46.56±3.47)分比( 46.89±3.82)分， P > 0.05］；观察组治疗 3周［( 32.80±3.22)分比( 44.10±3.67)分］、 5周［( 21.00±3.92)分比( 33.60±3.74)分］和 8周［( 9.20±3.71)分比( 20.40±3.75)分］后的 GAGS评分均低于对照组，差异有统计学意义( P < 0.05)；观察组和对照的不良反应发生率分别是 9.80％和 13.72％，组间对比差异无统计学意义( P = 0.539)。两组治疗期间出现的不良反应较轻微，病人均可耐受，未对治疗产生明显影响。结论相较于口服盐酸米诺环素联合红蓝光治疗仪治疗，加用 20％超分子水杨酸外涂治疗中重度痤疮，能够获得更加显著的治疗效果，病人的症状能够更加迅速有效地改善，且治疗的安全性能够得到保证。 |
| 英文摘要: |
| Objective To compare and analyze the clinical effect and adverse reaction of 20% hypermolecular salicylic acid combined with oral minocycline hydrochloride and red blue light therapy instrument in the treatment of patients with moderate and severeacne, and to provide a more safe and effective method for the treatment of moderate and severe acne.Methods One hundred and two patients with moderate and severe acne from May 2016 to February 2019 in Guidong People's Hospital of Guangxi Zhuang AutonomousRegion were selected and randomly assigned into study group and control group, with 51 cases in each group. In the control group, thetreatment method of an oral minocycline + red blue light therapeutic instrument is taken, while the study group was treated with supra?molecular salicylic acid on the basis of the treatment method of the control group. The clinical efficacy, (Global Acne Grading System,GAGS) score and adverse reactions of acne comprehensive grading system before and after treatment were compared between the twogroups.Results The total effective rate of the study group was 90.20%, the control group was 72.55%, and the difference between thegroups was statistically significant (P = 0.022).There was no significant difference in GAGS scores in the two groups before treatment [(46.56±3.47) vs. (46.89±3.82), P > 0.05].After 3 [(32.80±3.22) vs. (44.10±3.67)], 5 [(21.00±3.92) vs. (33.60±3.74)] and 8 weeks [(9.20± 3.71) vs. (20.40±3.75)] of treatment, the GAGS score of the study group was statistically significant compared with that of the control group (P < 0.05). The incidence of adverse reactions was 9.80% and 13.72% in the study group and the control group,respectively.Theadverse reactions of the patients in the group were mild and tolerable, which had no significant effect on the treatment.Conclusion Compared with the treatment of oral minocycline hydrochloride combined with red blue light therapy, the application of the super-molecular salicylic acid in the treatment of moderate to severe acne can obtain a more effective treatment effect, and the symptoms of thepatients can be improved more quickly and effectively, and the safety of the treatment can be ensured. |
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