| 胡杰,韩正祥,杜秀平.神经纤毛蛋白 1和血管内皮生长因子受体 2在肝细胞癌组织中的表达和临床意义[J].安徽医药,2021,25(3):512-515. |
| 神经纤毛蛋白 1和血管内皮生长因子受体 2在肝细胞癌组织中的表达和临床意义 |
| Expressions and clinical significance of NRP-1and VEGFR2 in hepatocellular carcinoma |
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| DOI：10.3969/j.issn.1009-6469.2021.03.020 |
| 中文关键词: 癌，肝细胞 血管内皮生长因子受体 2 神经纤毛蛋白 1 预后 |
| 英文关键词: Carcinoma, hepatocellular Vascular endothelial growth factor receptor 2 Neuropilin-1 Prognosis |
| 基金项目:江苏省“六大人才高峰” B类项目( 2014-WSW-040)；江苏省科教强卫创新团队( CXTDA2017034) |
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| 中文摘要: |
| 目的检测神经纤毛蛋白 1(NRP-1)和血管内皮生长因子受体 2(VEGFR2)在肝细胞癌组织及其癌旁正常肝组织中的表达情况，同时探讨 NRP-1和 VEGFR2的表达与肝细胞癌病人预后的关系。方法收集 2014年 11月至 2018年 11月在徐州医科大学附属医院肝胆外科行手术切除并经病理学确诊为肝细胞癌病人的肿瘤石蜡标本 40例及其癌旁正常肝组织标本 20例，应用免疫组织化学法检测肝细胞癌组织及正常肝组织中 NRP-1和 VEGFR2的表达情况。对病人进行至少为期 1年的随访，末次随访时间为 2019年 11月。结果 NRP-1、VEGFR2在肝细胞癌组织中的表达［(0.398±0.051)、(0.454±0.058)］明显高于正常肝组织［( 0.244±0.095)、(0.337±0.064)］(均 P<0.05)。 NRP-1、VEGFR2表达与肝细胞癌病人的肿瘤最大径、有无血管侵犯、分化程度、 TNM分期明显相关(均 P<0.05)，而与病人的性别、年龄、有无慢性肝炎病毒感染、甲胎蛋白水平、肿瘤数目、有无肝硬化、 Child-Pugh分级无关(均 P>0.05)。NRP-1和与 VEGFR2的表达呈正相关(r=0.789，P<0.001)。此外， NRP-1、VEGFR2表达高的肝细胞癌病人的术后 1年内复发率高［63.64%(14/22)、 55.00%(11/20)］，而 NRP-1、VEGFR2表达低的肝细胞癌病人的术后 1年复发率较低［5.56%(1/18)、 20.00%(4/20)］(均 P<0.05)。结论 NRP-1、VEGFR2在肝细胞癌组织中均有高表达，在肝细胞癌的发生和发展中起重要作用，而 NRP-1、VEGFR2的高表达提示病人预后不良。 |
| 英文摘要: |
| Objective To detect the expression of neuropilin 1 (NRP-1) and vascular endothelial growth factor receptor 2 (VEGFR2)in hepatocellular carcinoma (HCC) tissues and normal liver tissues adjacent to the cancer, and explore the relationship between the ex?pressions of NRP-1 and VEGFR2 with the prognosis of HCC patients.Methods The data of 40 HCC patients who underwent completeresection and pathological diagnosis from November 2014 to November 2018 in The Affiliated Hospital of Xuzhou Medical Universitywere collected. The expression of NRP-1 and VEGFR2 in 40 HCC tissues and 20 paracancerous liver tissues was detected by immuno?histochemistry. All patients were followed up after operation, the last followed-up time was November 2019.Results The expression rate of NRP-1 and VEGFR2 in HCC tissues [(0.398±0.051), (0.454±0.058)] was significantly higher than that in paracancerous normalliver tissues [(0.244±0.095), (0.337±0.064)] (all P<0.05). The expression of NRP-1 and VEGFR2 was significantly correlated with themaximum diameter, vascular invasion, differentiation and TNM stage of HCC patients(all P<0.05). There was no significant relationshipbetween sex, age, chronic hepatitis virus infection, alpha fetoprotein level, tumor number,liver cirrhosis and Child-Pugh grade(all P> 0.05).There was a positive correlation between the expression of NRP-1 and VEGFR2(r=0.789,P<0.001).In addition, the recurrence rate within 1 year after operation was higher in HCC patients with high expression of NRP-1 and VEGFR2 [63.64%(14/22), 55.00%(11/ 20)], while the recurrence rate was lower in patients with low expression of NRP-1 and VEGFR2 in HCC patients [5.56%(1/18), 20.00% (4/20)] (all P<0.05).Conclusion NRP-1 and VEGFR2 are highly expressed in HCC tissues, and may play an important role in the oc?currence and development of HCC, while the high expression of NRP-1 and VEGFR2 indicates poor prognosis. |
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