| 李蔚,王文静,章宏毅.光动力疗法与地塞米松治疗糜烂型口腔扁平苔癣的短中期疗效对比[J].安徽医药,2021,25(3):553-556. |
| 光动力疗法与地塞米松治疗糜烂型口腔扁平苔癣的短中期疗效对比 |
| Comparison of short and medium term efficacy between photodynamic therapy and dexamethasone in the treatment of erosive oral lichen planus |
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| DOI：10.3969/j.issn.1009-6469.2021.03.029 |
| 中文关键词: 扁平苔癣，口腔 光动力疗法 地塞米松 治疗结果 |
| 英文关键词: Lichen planus, oral Photodynamic therapy Dexamethasone Treatment outcome |
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| 中文摘要: |
| 目的观察光动力疗法治疗糜烂型口腔扁平苔癣的短中期临床疗效。方法选择荆州市第一人民医院口腔科就诊的糜烂型口腔扁平苔癣病人 60例，以抛硬币法随机分为试验组和对照组，每组 30例。试验组予以光动力疗法治疗病损部位；对照组予以地塞米松溶液( 5 mg/100 mL)每日 2次含漱治疗 4周。比较两组治疗结束时的病损愈合情况、病人自觉症状以及治疗后 1年、 2年的复发率。结果两组病损愈合情况差异无统计学意义( P> 0.05)。治疗后 2周试验组与对照组自觉症状比较差异有统计学意义［(25.5±15.4)%比( 39.3±14.1)%，P< 0.001］治疗后 4周两组自觉症状比较差异无统计学意义( P> 0.05)。试验组停治疗后 1年、 2年累积复发率与对照组差异无统计学意义，(P> 0.05)。结论两种方法对糜烂型口腔扁平苔癣均能显著促进病损愈合，光动力疗法在短时间内缓解病人疼痛症状方面效果不够显著，但最终效果堪比一线药物地塞米松，且复发率低，可推广使用，尤其可作为激素治疗无反应的糜烂型口腔扁平苔癣的替代疗法。 |
| 英文摘要: |
| Objective To observe the short and medium term efficacy of photodynamic therapy on the treatment of erosive oral li? chen planus (OLP).Methods A total of 60 patients with erosive OLP treated in the department of stomatology in the First People′sHospital of Jingzhou were randomly divided into experimental group (n = 30) and control group (n = 30). Patients in the experimentalgroup were treated by photodynamic therapy (PDT), while patients in the control group were treated with dexamethasone solution (5 mg/100 mL) twice a day. The clinical effects were observed and compared.Results There was no statistically significant difference in sign score changes between the 2 groups (P> 0.05). After 2 weeks′ treatment, there was significant differences in subjective symptom score between the 2 groups [(25.5±15.4)% vs. (39.3±14.1)%, P< 0.001]. After 4 weeks′ treatment, there was no significant differences in sub? jective symptom score between the 2 groups (P> 0.05). After 1 year and 2 years follow-up, the relapse of the experimental group waslower than that of the control group, but there were no statistically significant differences (P> 0.05).Conclusions Both treatments have remarkable curative effects for patients with erosive OLP. Photodynamic therapy is not effective in alleviating patients′ pain symp?toms in a short period of time, but the final effect is comparable to that of the first-line drug dexamethasone, and the recurrence rate islow. It can be widely used, especially as an alternative therapy for erosive oral lichen planus that does not respond to hormone therapy. |
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