| 钱斌,俞巍.双孔与三孔胸腔镜肺叶切除术治疗非小细胞肺癌临床疗效及相关因子水平的对比分析[J].安徽医药,2021,25(3):560-563. |
| 双孔与三孔胸腔镜肺叶切除术治疗非小细胞肺癌临床疗效及相关因子水平的对比分析 |
| A comparative analysis of the clinical efficacy and correlation factors of NSCLC treated with two-port and three-port thoracoscopic lobectomy |
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| DOI：10.3969/j.issn.1009-6469.2021.03.031 |
| 中文关键词: 肺切除术 胸腔镜检查 肿瘤坏死因子 α C反应蛋白质 白细胞介素 -6 丙二醛 癌，非小细胞肺 疼痛因子 |
| 英文关键词: Pneumonectomy Thoracoscopy Tumor necrosis factor-alpha C-reactive protein Interleukin-6 Malondialdehyde Carcinoma, non-small-cell lung Pain factor |
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| 中文摘要: |
| 目的比较双孔与三孔胸腔镜肺叶切除术治疗非小细胞肺癌( NSCLC)临床疗效及相关因子水平的差异。方法前瞻性将 2014年 1月至 2017年 12月武汉市红十字会医院收治的 NSCLC病人 156例纳入本研究，依照随机数字表法分为双孔胸腔镜肺叶切除术( DPTL)组与三孔胸腔镜肺叶切除术( TPTL)组各 78例。 DPTL组行 DPTL，TPTL组行 TPTL。观察两组手术相关指标，术前、术后 3d血清肿瘤坏死因子 α(TNF-α)、 C反应蛋白( CRP)白细胞介素 -6(IL-6)等炎性因子水平， 5-羟色胺、多巴胺、去甲肾上腺素( NE)等疼痛因子水平，谷胱甘肽过氧化物酶( GSH-Px)、超、氧化物歧化酶( SOD)、丙二醛等氧化应激因子水平，术后并发症， 3年内生存率等指标。结果两组各手术相关指标间均差异无统计学意义( P>0.05)。术后， DPTL组 TNF-α(2.21±0.25)μg/L、CRP(19.08±2.17)mg/L、IL-6(72.96±7.45)ng/L、5-羟色胺( 0.66±0.07)mmol/L、多巴胺( 23.84±2.46)ng/L、NE(2.78± 0.31)ng/L、GSH-Px(73.64±7.53)ng/L、SOD(156.84±16.86)μmol/L水平低于 TPTL组 TNF-α(3.89±0.42)μg/L、CRP(42.19±4.42) mg/L、IL-6(108.57±11.86)ng/L、5-羟色胺( 0.89±0.09)mmol/L、多巴胺( 37.93±3.84)ng/L、NE(4.35±0.45)ng/L、GSH-Px(52.63±5.44)ng/L、SOD(114.61±12.52)μmol/L水平，丙二醛( 5.43±0.57)mol/L水平高于 TPTL组丙二醛( 9.85±1.27)mol/L水平( P<0.05)。 DPTL组术后并发症发生率 7.69%(6/78)、 3年生存率 52.56%(41/78)与 TPTL组术后并发症发生率 11.54%(9/78)、 3年生存率48.72%(38/78)均差异无统计学意义( P>0.05)。结论 DPTL治疗 NSCLC创伤小，对机体产生的伤害性刺激相对 TPTL小，可减少疼痛因子生成，缓解病人炎性反应及应激反应，有利于病人康复。 |
| 英文摘要: |
| Objective To compare the clinical efficacy and related factors between two-port and three-port thoracoscopic lobectomy in the treatment of non-small cell lung cancer (NSCLC). Methods A total of 156 patients with NSCLC admitted to Wuhan Red CrossHospital from January 2014 to December 2017 were prospectively included in this study. They were randomly divided into two-port vid? eo-assisted thoracoscopic lobectomy (DPTL) group and three-port video-assisted thoracoscopic lobectomy (TPTL) group, with 78 casesin each group. DPTL group was given DPTL, TPTL group was given TPTL. The surgical indicators of the two groups were observed, in?cluding the levels of inflammatory factors such as tumor necrosis factor-α (TNF -α), C -reactive protein (CRP), interleukin -6 (IL-6), pain factors such as serotonin (5-HT), dopamine (DA), norepinephrine (NE), glutathione peroxidase (GSH-PX), superoxide dismutase(SOD), malondialdehyde (MDA) and other oxidative stress factors, postoperative complications and survival within 3 years. Results There was no significant difference between the two groups in various surgical related indexes (P > 0.05). After operation, the levels of TNF -α (2.21 ± 0.25) μ g/L, CRP (19.08 ± 2.17) mg/L, IL-6 (72.96 ± 7.45) ng/L, 5-hydroxytryptamine (0.66 ± 0.07) mmol/L, dopamine |
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