| 楚师成,高学军,宋云浩,等.信号素 3F及其受体神经纤毛蛋白在肿瘤微环境中的研究进展[J].安徽医药,2021,25(4):641-644. |
| 信号素 3F及其受体神经纤毛蛋白在肿瘤微环境中的研究进展 |
| Research progress of SEMA3F and its receptor NRP in tumor microenvironment |
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| DOI：10.3969/j.issn.1009-6469.2021.04.002 |
| 中文关键词: 信号素 3F 神经纤毛蛋白质类 肿瘤微环境 综述 |
| 英文关键词: Semaphorin-3F Neuropilins Tumor microenvironment Review |
| 基金项目: |
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| 中文摘要: |
| 肿瘤微环境可以经不同信号通路分泌多种血管生成因子、炎性细胞因子和趋化因子，利用多种间质细胞组成的庞杂系统加快肿瘤的进展。其中信号素(semaphorins，SEMA)是肿瘤微环境的重要调节因子，信号素 -神经纤毛蛋白(SEMA-NRP)复合物参与肿瘤抑制途径，本研究期望通过对肿瘤微环境中信号素 3F(semaphorins 3F，SEMA3F)及其受体神经纤毛蛋白(neuropilin，NRP)作用的综述，为将来对肿瘤进行早期靶向治疗提供依据。 |
| 英文摘要: |
| Tumor microenvironment is a complex system containing a variety of Leydig cells, which secrete a variety of inflammatorycytokines, chemokines and angiogenic factors through signaling pathways to accelerate tumor development. Among them, semaphorins(SEMA) is an important regulator of the tumor microenvironment, and semaphorins-neuropilin (SEMA-NRP) complex is involved in thetumor inhibition pathway. The role of SEMA3F and its receptor neuropilin (NRP) in tumor microenvironment is reviewed with a view tothe early targeted therapy of tumors in the future. |
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