| 冉琪,胡亚飞,游玉峰.超声造影表现与肝硬化背景下肝细胞癌组织病理、分化程度及预后的关系分析[J].安徽医药,2021,25(4):681-685. |
| 超声造影表现与肝硬化背景下肝细胞癌组织病理、分化程度及预后的关系分析 |
| Analysis of the relationship between contrast-enhanced ultrasound findings and histopathology, differentiation and prognosis of hepatocellular carcinoma under the background of liver cirrhosis |
| |
| DOI：10.3969/j.issn.1009-6469.2021.04.011 |
| 中文关键词: 癌，肝细胞 超声心动描记术 肝硬化 组织病理 因果律 预后 |
| 英文关键词: Carcinoma, hepatocellular Echocardiography Liver cirrhosis Histopathology Causality Prognosis |
| 基金项目:国家自然科学基金(81660291) |
|
| 摘要点击次数: 1316 |
| 全文下载次数: 509 |
| 中文摘要: |
| 目的探讨超声造影(CEUS)表现与肝硬化背景下肝细胞癌(HCC)组织病理、分化程度及预后的关系。方法选择 2014年 1月至 2017年 1月在恩施州中心医院行根治性切除术的 174例肝硬化背景下 HCC病人为研究对象。收集病人的一般临床资料及微血管浸润(MVI)、微血管密度(MVD)及增殖细胞核抗原(Ki-67)等病理资料。记录肝 CEUS动脉期、门脉期、延迟期等增强特征。分析 CEUS特征与 MVI、MVD、Ki-67、肿瘤分化程度及预后的关系。结果 Ki-67阳性组 HCC病人肿瘤低 /中分化的发生率 90.1%(91/101)较 Ki-67阴性组 74.0%(54/73)显著升高(P<0.05)。动脉期不均匀增强、门脉期低增强、延迟期低增强的 HCC病人 Ki-67阳性发生率［69.7%(76/109)比 38.5%(25/65)、 67.5%(79/117)比 38.6%(22/57)、 69.7%(53/76)比 49.0%(48/ 98)］及肿瘤低 /中分化发生率［90.2%(101/112)比 71.0%(44/62)、 89.1%(98/110)比 73.4%(47/64)、 88.7%(102/115)比 72.9%(43/ 59)］显著升高(P<0.05)。延迟期低增强的 HCC病人 MVI阳性发生率［80.2%(65/81)比 65.6%(61/93)］显著升高(P<0.05)。不同 MVD的 HCC病人间 CEUS特征差异无统计学意义(P>0.05)。动脉期不均匀增强的 HCC病人早期复发的发生率［37.7%(40/ 106)比 27.9%(19/68)］显著升高(P<0.05)。结论 CEUS特征与肝硬化背景下 HCC病人组织病理、分化程度等显著相关，并可能有助于预测病人术后的复发情况。 |
| 英文摘要: |
| Objective To investigate the relationship between contrast-enhanced ultrasound (CEUS) findings and the histopathology, differentiation and prognosis of hepatocellular carcinoma (HCC) in the background of liver cirrhosis.Methods A total of 174 patients with HCC under the background of liver cirrhosis who underwent radical resection in Enshi Central Hospital from January 2014to January 2017 were selected as the research subjects. The clinical data and pathological data such as microvascular invasion (MVI),microvascular density (MVD), and Proliferating cell nuclear antigen (Ki-67) of HCC patients were collected. The enhancement featuressuch as arterial phase, portal phase, and delayed phase of liver CEUS were recorded. The relationship between CEUS characteristicsand MVI, MVD, Ki-67, tumor differentiation and prognosis were analyzed.Results The incidence of low/medium differentiation of HCC patients in Ki-67 positive group 90.1% (91/101) was significantly higher than that in Ki-67 negative group 74.0% (54/73) (P< 0.05). The incidence of Ki-67 positive and low/medium differentiation in HCC patients with inhomogeneous enhancement at arterial phase [69.7% (76/109) vs. 38.5% (25/65), 90.2% (101/112) vs. 71.0% (44/62)], low enhancement at portal phase [67.5% (79/117) vs. 38.6% (22/57), 89.1% (98/110) vs. 73.4% (47/64)], and low enhancement at delay phase [69.7% (53/76) vs. 49.0% (48/98), 88.7% (102/ 115) vs. 72.9% (43/59)] were significantly increased (P<0.05). The incidence of MVI positive in HCC patients with low enhancement at delay phase [80.2% (65/81) vs. 65.6% (61/93)] was significantly increased (P<0.05). There was no significant difference in CEUS characteristics between HCC patients with different MVD (P>0.05). The incidence of early recurrence in HCC patients with inhomogeneous enhancement at arterial phase [37.7% (40/106) vs. 27.9% (19/68)] was significantly increased (P<0.05).Conclusion CEUS characteristics were significantly related to the histopathology and degree of differentiation of HCC patients in the background of liver cirrhosis,and may help predict the recurrence of HCC patients after surgery. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
