| 陈东,严激,陈康玉,等.高同型半胱氨酸与急性心肌梗死及短期心脏血管不良事件发生的相关性[J].安徽医药,2021,25(4):760-763. |
| 高同型半胱氨酸与急性心肌梗死及短期心脏血管不良事件发生的相关性 |
| Association of hyperhomocysteine with the occurrence of acute myocardial infarction and short-term MACE |
| |
| DOI：10.3969/j.issn.1009-6469.2021.04.031 |
| 中文关键词: 心肌梗死 高同种半胱氨酸血症 尿酸 吸烟 预后 |
| 英文关键词: Myocardial infarction Hyperhomocysteinemia Uric acid Smoking Prognosis |
| 基金项目: |
|
| 摘要点击次数: 1844 |
| 全文下载次数: 773 |
| 中文摘要: |
| 目的探讨高同型半胱氨酸(H-Hcy)与急性心肌梗死及短期 MACE(心脏血管不良事件)发生的相关性。方法回顾性研究 2013年 1月至 2019年 6月在合肥市第三人民医院心内科住院急性心肌梗死 124例，根据 Hcy水平分为 H-Hcy组(> 15umoI/L，n=59例)和 Hcy组(≤15umoI/L，n=65例)，分析两组病人年龄、性别、疼痛、吸烟、饮酒、低密度脂蛋白胆固醇(LDL)、血尿酸(SUA)、高血压、急性心肌梗死类型差异性及出院后 6个月随访心脏不良事件(Major adverse cardiac events MACE)发生风险。结果 H-Hcy组病人吸烟(49.2%比 29.2%，χ2=5.174，P=0.023)、 SUA［(2.58±0.143)比(2.50±0.123)t=3.686，P<0.01］、 LDL［(0.36±0.19)比(0.43±0.13)t=?2.625，P=0.01］明显高于 Hcy组，差异统计学有意义。 Pearson相关性分析，显示 Hcy与 SUA(r=0.721，P<0.01)、吸烟(r=0.407，P，<0.01)呈正性相关。 Kaplan-Meire生存分析显示: 6个月短期随访 H-Hcy组累积 MACE发生率高于 Hcy组(82.8%比 48.4％， P<0.01)(log-rank χ2=55.09，P<0.01)。多因素 COX分析显示: H-Hcy(HR=1.315，95％ CI:1.225~1.414，P<0.01)、 SUA(HR=1.304，95％CI:1.210~1.412，P=0032)、吸烟(HR=1.089 95％CI:1.017~1.307，P=0.024)是影响 MACE发生的独立危险因素。结论 H-Hcy、SUA、吸烟与急性心肌梗死和短期 MACE发生具有重要相关性，其中 H-Hcy是 MACE的最独立预测因子。 |
| 英文摘要: |
| Objective To investigate the correlation between high homocysteine (H-Hcy) level and acute myocardial infarction and short-term major adverse cardiovascular events (MACE).Methods A retrospective study was carried out on 124 cases of acute myocardial infarction in the cardiology admitted to Department of Cardiology in Third People's Hospital of Hefei from January 2013 to June2019. According to the Hcy levels the patients were assigned into H-Hcy (> 15 umol/L) group (n = 59) and Hcy (≤15 umol/L, n = 65)group to analyze age, gender, pain, smoking, alcohol consumption, the low density lipoprotein cholesterol (LDL), serum uric acid (SUA),hypertension, acute myocardial infarction types and 6-month post-discharge follow-up of the incidence of MACE.Results Compared with Hcy group, smoking (49.2% vs. 29.2%, χ2=5.174, P=0.023), SUA [( 2.58±0.143) vs. (2.50±0.123), t=3.686, P<0.01) and LDL [(0.36±0.19) vs. (0.43±0.13), t=-2.625,P= 0.01) in H-Hcy group were significantly higher with statistical difference. Pearson correlation analysis showed that Hcy was positively correlated with SUA(r=0.721, P<0.01)and smoking(r=0.407, P<0.01). Kaplan-Meire survival analysis showed that the cumulative incidence of MACE during six-month short-term follow-up in the H-Hcy group was higher than that in the Hcy group (82.8% vs. 48.4%,P<0.01)(log-rank χ2=55.09,P<0.01). Multivariate Cox analysis showed that H-Hcy level (HR=1.315, 95％ CI: 1.225-1.414, P<0.01) and SUA (HR=1.304, 95％ CI: 1.210-1.412, P=0.032) and smoking (HR=1.089, 95％ CI: 1.017-1.307, P=0.024) were independent risk factors of MACE.Conclusion H-Hcy, SUA and smoking are critically correlated with acute myocardial infarction and short-term MACE. H-Hcy is an independent factor in predicting the occurrence of short-term MACE. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
