| 李乔,张博.黄芪桂枝五物汤联合木丹颗粒治疗糖尿病周围神经病变(气虚血瘀证) 41例[J].安徽医药,2021,25(5):1052-1056. |
| 黄芪桂枝五物汤联合木丹颗粒治疗糖尿病周围神经病变(气虚血瘀证) 41例 |
| Exploration of the effect of Huangqiguizhiwuwu decoction combined with Mudan granules in 41 cases of diabetic peripheral neuropathy (Qi deficiency and blood stasis syndrome) |
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| DOI：10.3969/j.issn.1009-6469.2021.05.052 |
| 中文关键词: 糖尿病神经病变 黄芪桂枝五物汤 木丹颗粒 气虚血瘀证 作用 |
| 英文关键词: Diabetic neuropathies Huangqiguizhiwuwu decoction Mudan granules Qi deficiency and blood stasis syn |
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| 目的探讨黄芪桂枝五物汤联合木丹颗粒对糖尿病周围神经病变( DPN)(气虚血瘀证)的作用。方法选取 2015年 2月至 2018年 4月中国中医科学院广安门医院南区收治的 DPN(气虚血瘀证)病人 164例，采用随机数字表法分为四组，即西药组、颗粒组、汤药组、联合组，每组 41例，分别给予常规西药、常规西药 +木丹颗粒、常规西药 +黄芪桂枝五物汤、常规西药 +黄芪桂枝五物汤 +木丹颗粒治疗，均持续 8周。对比治疗前后主症、次症积分和总积分，治疗前后神经传导速度，临床疗效，治疗前后血液流变学变化，安全性。结果四组治疗后较治疗前主症［西药组( 7.41±1.50)分比( 14.32±2.05)分、颗粒组( 4.15±1.21)分比( 14.17±2.00)分、汤药组( 4.10±1.23)分比( 14.11±2.01)分、联合组( 2.03±0.56)分比( 14.20±2.05)分］、次症积分［西药组( 8.52± |
| 英文摘要: |
| Objective To explore the effect of Huangqiguizhiwuwu decoction combined with Mudan granules in diabetic peripheral neuropathy (DPN) (Qi deficiency and blood stasis syndrome).Methods Form February 2015 to April 2018,164 patients with DPN (Qideficiency and blood stasis syndrome) admitted to South District of Guang′anmen Hospital of China Academy of Chinese Medical Sciences were randomly divided into four groups, namely, western medicine group, granule group, decoction group and combination group.They were treated with routine western medicine, routine western medicine + Mudan granules, routine western medicine + Huangqiguizhiwuwu decoction, routine western medicine + Huangqiguizhiwuwu decoction + Mudan granules for 8 weeks. The main symptoms, secondary symptoms and total scores before and after treatment, nerve conduction velocities before and after treatment, clinical efficacy,hemorheological changes before and after treatment, and safety were compared.Results After treatment, the scores of main symptoms [western medicine group (7.41±1.50) cases vs. (14.32±2.05) cases, granule group (4.15±1.21) cases vs. (14.17±2.00) cases, decoction group (4.10±1.23) cases vs. (14.11±2.01) cases,combination group (2.03±0.56) cases vs. (14.20±2.05) cases], secondary symptoms[western medicine group (8.52±2.03) cases vs. (16.09±2.48) cases,granule group (5.20±1.43) cases vs. (16.11±2.36) cases, decoction group (5.12±1.40) cases vs. (16.05±2.44) cases,combination group (2.30±0.55) cases vs. (16.22±2.41) cases] and total scores[western medicine group (15.93±2.40) cases vs. (30.41±4.48) cases,granule group (9.35±1.67) cases vs. (30.28±4.50) cases,decoction group (9.22±1.72) cases vs. (30.16±4.36) cases,combination group (4.33±0.71) cases vs. (30.42±4.38) cases] of the four groups decreased (P < 0.05), whilethose of the combined group < granule group / decoction group < western medicine group. After treatment, the nerve conduction velocityincreased in the four groups (P < 0.05), and in the combined group > granule group / decoction group > western medicine group. Therewere significant differences in the distribution of curative effect and total effective rates among the four groups (P < 0.05). The total effective rate was compared among the groups, the combined group > granule group / decoction group > western medicine group. Aftertreatment, the hematocrit (Ht) of granule group, decoction group and combination group decreased (P < 0.05), while there was no significant change in western medicine group (P > 0.05), and the combined group < granule group / decoction group < western medicinegroup. After treatment, fibrinogen (Fbg), plasma viscosity (Vp), whole blood viscosity (Va) of the four groups decreased (P < 0.05), andthe combined group < granule group / decoction group < western medicine group. There was no significant difference in the incidencesof adverse reactions among the four groups (P > 0.05).Conclusion The treatment of DPN (Qi deficiency and blood stasis syndrome)with Huangqiguizhiwuwu decoction and Mudan granules on the basis of conventional western medicine can alleviate symptoms, increase nerve conduction velocity, enhance curative effect and improve hemorheology. The combination of the two is better and safe. |
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