| 廖梅,陈小平,蒙其其.复方仙人掌软膏的制备及总黄酮的含量测定[J].安徽医药,2021,25(6):1109-1113. |
| 复方仙人掌软膏的制备及总黄酮的含量测定 |
| Preparation process of compound cactus ointment and determination of total flavonoids |
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| DOI：10.3969/j.issn.1009-6469.2021.06.011 |
| 中文关键词: 中草药 黄酮类 工艺学，制药 复方仙人掌软膏 制备工艺 腮腺炎 总黄酮 |
| 英文关键词: Drugs, Chinese herbal Flavones Technology, pharmaceutical Compound cactus ointment Preparation pro |
| 基金项目:广东省中医药局科研项目( 20171267)；梅州市社会发展科技计划项目( 2017B069)；嘉应学院 2019年大学生创新创业训练计划项目( 201910582276)；广东省高等教育“冲补强”提升计划重点建设学科(农业资源与环境)建设项目(粤教科函〔 2018〕181号)；广东省科技计划项目( 2020B121201013) |
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| 中文摘要: |
| 目的研究复方仙人掌软膏的最佳制备工艺并测定其总黄酮含量。方法在单因素试验的基础上，以色泽均匀度，质地细腻度，涂抹分散性，清洗容易度，离心稳定性和耐寒耐热稳定性为评价指标，以基质成型性影响较大的硬脂酸、单硬脂酸甘油酯、三乙醇胺和十二烷基硫酸钠用量为因素，通过正交设计试验法对复方仙人掌软膏进行制备工艺优化，并测定该软膏中的总黄酮含量。结果优化后的软膏处方基质用量为硬脂酸 1.0 g，单硬脂酸甘油酯 1.0 g，三乙醇胺 0.16 g，十二烷基硫酸钠 0.14 g；乳化温度为 75 ℃，乳化时间为 5 min。最优工艺制备的 3批软膏中总黄酮含量分别为( 32.62±0.15)mg/g、(33.19±0.23)mg/g、 |
| 英文摘要: |
| Objective To study the preparation process of compound cactus ointment and determine the content of its total flavonoids.Methods On the basis of single factor experiment, the appearance of characters, centrifugal stability, cold-resistant stability and heat-resistant stability as the indexes, along with the dosage of stearic acid, glycerin monostearate, triethanolamine and sodium dodecyl sulfate as the factors, orthogonal design L9 (34) was carried out to optimize the preparation process of compound cactus ointment,and the total flavonoid content in the ointment was determined.Results The best formulation of ointment matrix was 1.0 g stearic acid,1.0 g glyceryl monostearate, 0.16 g triethanolamine and 0.14 g sodium dodecyl sulfate. The emulsification temperature was 75 ℃ andemulsification time was 5 min. The compound cactus ointment prepared had a good property, the total flavonoids content was (32.62±0.15) mg/g, (33.19±0.23) mg/g and (31.46±0.09) mg/g, respectively, and the average content was (32.42±0.77) mg/g. The RSD was2.39%.Conclusion The quality of ointment prepared according to the optimal preparation process is stable, the process is simple, stable and feasible. |
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