| 刘波,王少敏,袁岸龙.肝癌病人肠道菌群与血氨、血清胆碱酯酶的相关性[J].安徽医药,2021,25(6):1128-1131. |
| 肝癌病人肠道菌群与血氨、血清胆碱酯酶的相关性 |
| Correlation between intestinal flora and serum ammonia and cholinesterase in patients with liver cancer |
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| DOI：10.3969/j.issn.1009-6469.2021.06.016 |
| 中文关键词: 肝肿瘤 肠道菌群 血氨 血清胆碱酯酶 |
| 英文关键词: Liver neoplasms Intestinal flora Blood ammonia |
| 基金项目:湖北省科技计划项目( WJ2018H0109) |
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| 中文摘要: |
| 目的探讨肝癌病人体内肠道菌群与血氨、血清胆碱酯酶的关系。方法前瞻性选取 2017年 8月至 2018年 12月孝感市中心医院收治的 98例肝癌病人为肝癌组，同期肝硬化病人 92例为对照组。采用微生物培养法检测肠道菌群情况；连续监测法检测血氨水平；假性胆碱酯酶速率法检测胆碱酯酶的表达；分析肠道菌与血氨、血清胆碱酯酶的相关性。结果肝癌组病人肠道内拟杆菌( 7.28±1.82)lgCFU/g、乳杆菌( 7.17±1.91)lgCFU/g、真杆菌( 6.85±1.93)lgCFU/g、双歧杆菌( 5.89±1.68)lgCFU/g、消化球菌( 5.89±1.68)lgCFU/g、酵母菌( 4.36±0.79)lgCFU/g、肠杆菌( 7.73±1.25)lgCFU/g以及葡萄球菌( 3.64±1.24)lgCFU/g均低于对照组的( 8.34±2.06)lgCFU/g、(8.03±1.87)lgCFU/g、(7.56±2.14)lgCFU/g、(8.87±2.43)lgCFU/g、(6.61±1.47)lgCFU/g、(6.28±1.35) lgCFU/g、(8.57±1.12)lgCFU/g及( 5.23±1.37)lgCFU/g(P<0.05)。肝癌组血氨水平( 70.01±6.67)μmol/L明显高于对照组的( 25.02±3.58)μmol/L(P<0.05)，血清胆碱酯酶水平( 2 805.23±224.72)U/L明显低于对照组的( 7 481.54±637.12)U/L(P<0.05)。肝癌病人不同临床分期血氨水平从高到低依次为 Ⅳ、Ⅲ、Ⅱ、Ⅰ期，血清胆碱酯酶水平从高到低依次为 Ⅰ、Ⅱ、Ⅲ、Ⅳ期，两两比较均差异有统计学意义( P<0.05)。肝癌病人体内拟杆菌、双歧杆菌、酵母菌、肠杆菌及葡萄球菌与血氨水平呈负相关( P<0.05)，与血清胆碱酯酶水平呈正相关( P<0.05)。结论肝癌病人肠道菌群数量、血清胆碱酯酶水平降低，血氨水平升高，三者可能共同影响肝癌发生、发展。 |
| 英文摘要: |
| Objective To explore the relationship between intestinal flora and serum ammonia (NH3) and cholinesterase (ChE) in patients with liver cancer.Methods Ninety-eight patients with liver cancer, who were treated in Central Hospital of Xiaogan from August2017 to December 2018, were prospectively chosen as liver cancer group, and 92 patients with cirrhosis treated during the same periodas control group. The intestinal flora was detected by microbial culture method, the blood NH3 level was detected by continuous monitoring method, and the expression of ChE was detected by pseudo ChE rate method. The correlations between intestinal bacteria andblood NH3, serum ChE were analyzed.Results Bacteroides (7.28±1.82) lgCFU/g, Lactobacillus (7.17±1.91) lgCFU/g, Eubacterium(6.85±1.93) lgCFU/g, Bifidobacterium (5.89±1.68) lgCFU/g, Peptococcus (5.89±1.68) lgCFU/g, yeast (4.36±0.79) lgCFU/g, Enterobacter (7.73±1.25) lgCFU/g and Staphylococcus (3.64±1.24) lgCFU/g in patients of liver cancer group were all lower than those of controlgroup [(8.34±2.06) lgCFU/g, (8.03±1.87) lgCFU/g, (7.56±2.14) lgCFU/g, (8.87±2.43) lgCFU/g, (6.61±1.47) lgCFU/g, (6.28±1.35) lgCFU/g, (8.57±1.12) lgCFU/g and (5.23±1.37) lgCFU/g; P<0.05]. The level of NH3 in liver cancer group was significantly higher than that in control group [(70.01±6.67)μmol/L vs. (25.02±3.58)μmol/L; P<0.05], and the serum level of ChE in liver cancer group was significantly lower than that in control group [(2 805.23±224.72)U/L vs. (7 481.54±637.12)U/L; P< 0.05]. The levels of NH3 in different clinical stages of liver cancer patients were in the order of Ⅳ, Ⅲ, Ⅱ and Ⅰ from high to low, and the levels of serum ChE were in the orderof Ⅰ, Ⅱ, Ⅲ and Ⅳ from high to low; The pairwise comparison showed statistically significant difference (P<0.05). Bacteroides, bifidobacterium,yeast,EnterobacterandStaphylococcuswerenegativelycorrelatedwithserum NH3level(P <0.05) and positively correlated with serum ChE level (P<0.05).Conclusion The number of intestinal microflora, the decreased level of serum ChE and the increased NH3(blood) level of in patients with liver cancer may affect the occurrence and development of liver cancer. |
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