| 王葳,曹义娟,汤美玲,等.人绒毛膜促性腺激素在冻融胚胎移植激素替代周期内膜转化日的应用[J].安徽医药,2021,25(6):1154-1158. |
| 人绒毛膜促性腺激素在冻融胚胎移植激素替代周期内膜转化日的应用 |
| Application of human chorionic gonadotropin on the day of endometrial transformation in the hormone replacement therapy of frozen-thawed embryo transfer |
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| DOI：10.3969/j.issn.1009-6469.2021.06.023 |
| 中文关键词: 胚胎移植 妊娠结局 子宫内膜 激素替代周期 人绒毛膜促性腺激素 |
| 英文关键词: Embryo transfer Pregnancy outcome Endometrium Hormone replacement therapy Human chorionic gonadotropin |
| 基金项目:徐州市科技计划项目( KC17104) |
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| 中文摘要: |
| 目的探讨冻融胚胎移植( FET)激素替代周期( HRT)内膜转化日低黄体生成素( LH)时肌注人绒毛膜促性腺激素(hCG)对妊娠结局的影响。方法回顾性分析 2018年 1月至 2019年 12月在皖北煤电集团总医院生殖医学科行 FET激素替代方案助孕共 271个周期的临床资料。根据内膜转化日低 LH时是否肌注 hCG分为 hCG组( 45周期)和对照组( 95周期)，同时期未使用 hCG治疗的病人，根据内膜转化日 LH值分为高 LH组( LH≥13 U/L，131周期)和低 LH组(即前面对照组， LH<13 U/L，95周期)分别比较各组的临床指标。结果 hCG组胚胎种植率［37.65%(32/85)］、临床妊娠率［62.22%(28/45)］高于对照组 |
| 英文摘要: |
| Objective To explore the effect of intramuscular injection of human chorionic gonadotropin (hCG) on pregnancy outcome during the hormone replacement therapy(HRT)of frozen-thawed embryo transfer(FET)with low luteinizing hormone (LH) on endometrial transformation day.Methods The clinical data of 271 cycles of FET hormone replacement therapy, which was carried out inReproductive Medicine Department of the General Hospital of Wanbei Coal-Electricity Group from January 2018 to December 2019,were analyzed retrospectively. According to whether or not hCG was intramuscularly injected at low LH on endometrial transformationday, patients were assigned into hCG group (45 cycles) and control group (95 cycles). Patients who did not use hCG at the same timewere assigned into high LH group (LH≥13 U/L, 131 cycles) and low LH group (control group, LH<13 U/L, 95 cycles) according to thevalue of LH on endometrial transformation day. The clinical indexes of all groups were compared.Results The embryo implantationrate [37.65% (32/85)] and the clinical pregnancy rate [62.22% (28/45)] of hCG group were higher than those of control group [25.55%(46/180), 43.43% (43/99)](P< 0.05). The body mass index (BMI), estradiol(E2)value on endometrial transformation day and early abortion rate [4.41% (3/68)] of the high LH group were lower than those of the low LH group [17.07% (7/41)] (P< 0.05). And the embryo implantation rate [34.66% (87/250)] of the high LH group was higher than that of the low LH group [25.55% (46/180)] (P< 0.05).Conclu? sions Low LH in the hormone replacement therapy of frozen-thawed embryo transfer is not conductive to embryo implantation andpregnancy maintenance. Intramuscular injection of hCG on endometrial transformation day with low LH could improve embryo implantation rate and clinical pregnancy rate, but could not reduce the early abortion rate. |
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