| 温艳美,程浩.玻璃酸钠联合重组人表皮生长因子滴眼液治疗干眼症的临床效果分析[J].安徽医药,2021,25(6):1229-1232. |
| 玻璃酸钠联合重组人表皮生长因子滴眼液治疗干眼症的临床效果分析 |
| Analysis of the clinical effect of sodium hyaluronate combined with rhEGF eye drops in treating patients with xerophthalmia |
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| DOI：10.3969/j.issn.1009-6469.2021.06.041 |
| 中文关键词: 干眼症 玻璃酸钠 重组人表皮生长因子滴眼液 临床效果 炎性因子 |
| 英文关键词: Xerophthalmia Sodium hyaluronate RhEGF eye drops Clinical effect Inflammatory cytokines |
| 基金项目:广东省科学技术厅公益研究与能力建设专项资金项目( 2014A020212365) |
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| 中文摘要: |
| 目的探讨玻璃酸钠联合重组人表皮生长因子( rhEGF)滴眼液在干眼症病人中的临床效果。方法选取广州医科大学附属惠州医院 2018年 8月至 2019年 2月就诊的 120例干眼症病例，按随机数字表法分为对照组( n=60，应用 0.1%玻璃酸钠滴眼液治疗， 4次/天)研究组( n=60，在对照组的基础上加用 rhEGF滴眼液治疗， 2次/天)，均 1滴/次，用药 6周。比较两组病人治疗效果、肿瘤坏死因子，α(TNF-α)和白细胞介素 -6(IL-6)水平和泪膜破裂时间( BUT)、泪液分泌长度、眼表疾病指数(OSDI)评分。结果研究组总有效率 95.0%(57/60)高于对照组 83.3%(50/60)(P<0.05)；干预后，研究组病人 BUT延长、泪液分泌量增加、 OSDI评分降低(P<0.05)；研究组干预后，泪液 IL-6和 TNF-α水平明显低于对照组(P<0.05)。结论玻璃酸钠联合 rhEGF滴眼液治疗干眼症临床效果显著。 |
| 英文摘要: |
| Objective To investigate the clinical effect of sodium hyaluronate combined with recombinant human epidermal growthfactor (rhEGF) eye drops in patients with xerophthalmia.Methods A total of 120 xerophthalmia cases from the Huizhou Hospital affiliated to Guangzhou Medical University from August 2018 to February 2019 were selected. According to a random number table, patientswere assigned into a control group (n=60, with 0.1% sodium hyaluronate eye drops for treatment , 4 times/day) and the study group (n= 60, plus rhEGF eye drops on the basis of the control group, 2 times/day), 1 drop/time, medication for 6 weeks. The treatment effect, levels of TNF-α and IL-6, tear film burst time (BUT), tear secretion length, and ocular surface disease index (OSDI) scores were comparedbetween the two groups of patients.Results The total effective rate of the study group was 95.0% (57/60) higher than that of the control group 83.3% (50/60) (P<0.05), after the intervention, patients in the study group had prolonged BUT, increased tear secretion, and decreased OSDI score (P<0.05). After the intervention of the study group, the levels of IL-6 and TNF-α in tears were significantly lower than those of the control group (P<0.05).Conclusion Sodium hyaluronate combined with rhEGF eye drops has a significant clinical effect in the treatment of xerophthalmia. |
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