| 陈云江,龚艳春.氨氯地平联合厄贝沙坦不同给药时间对原发性高血压病人血压变异性和血压晨峰现象的影响[J].安徽医药,2021,25(6):1236-1239. |
| 氨氯地平联合厄贝沙坦不同给药时间对原发性高血压病人血压变异性和血压晨峰现象的影响 |
| Effect of different administration time of amlodipine combined with irbesartan on blood pressure variability and morning blood pressure peak in patients with essential hypertension |
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| DOI：10.3969/j.issn.1009-6469.2021.06.043 |
| 中文关键词: 高血压 药物时间疗法 氨氯地平 厄贝沙坦 血压变异系数 血压晨峰 |
| 英文关键词: Hypertension Drug chronotherapy Amlodipine Irbesartan Coefficient of variability Blood pressure morning peak |
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| 目的比较氨氯地平和厄贝沙坦联合用药治疗原发性高血压病人不同服药时间的血压变异性、血压晨峰控制效果。方法回顾性选取符合要求的于 2014年 2月至 2017年 12月来上海交通大学医学院附属瑞金医院诊治的 84例轻中度原发性高血压， A组于 06:30服用苯磺酸氨氯地平片 5 mg、厄贝沙坦片 150 mg；B组于 18:30服用苯磺酸氨氯地平片 5 mg、厄贝沙坦片 150 mg，持续治疗 10周。治疗后开展随访工作，记录不良事件发生情况，通过 DMS-ABP动态血压监测仪测量出所有研究对象的 24 h、日间、夜间的平均舒张压( DBP)和收缩压( SBP)并计算出血压变异系数以及血压晨峰情况。结果 ①A组治疗后随访临床不良事件发生率( 5.00%)低于 B组( 27.27%)(χ2=7.，48，P=0.006)。 ②经过治疗后， B组病人的 24 h、日间、夜间的平均 DBP和 SBP低于 A组( tDBP=6.154、1.941、2.099，tSBP=5.629、2.518、2.688，均 P<0.05)。 ③经过治疗后， B组血压变异系数低于 A组(tDBP=1.812、2.938、2.598，tSBP=4.577、2.938、12.642，均 P<0.05)。 ④经过治疗后， B组血压晨峰值低于 A组( t=6.732，P<0.001)。结论氨氯地平与厄贝沙坦联合用药，晚间同时服用的血压变异性和血压晨峰控制效果优于早晨同时服用。 |
| 英文摘要: |
| Objective To compare the blood pressure variability and the control effect of morning blood pressure surge in patientswith essential hypertension treated with amlodipine and irbesartan at different time.Methods Eighty-four patients with mild to moderate essential hypertension who met the inclusion criteria and came to Ruijin Hospital Affiliated to Shanghai Jiao Tong University Schoolof Medicine for treatment from February 2014 to December 2017 were selected retrospectively. Group A received 5 mg amlodipine besylate tablets and 150 mg irbesartan tablets at 06:30 and group B received 5 mg amlodipine besylate tablets and 150 mg irbesartan tablets at 18:30 for 10 weeks, respectively. Follow-up was carried out after treatment, and adverse events were recorded. The mean diastolic blood pressure (DBP) and systolic blood pressure (SBP) of all subjects at 24 h, daytime and night were measured by DMS-ABP dynamic blood pressure monitor, and the coefficient of variation of blood pressure and the morning blood pressure surge were calculated.Results The incidence of adverse events in group A (5.00%) after treatment was lower than that in group B (27.27%) (χ2=7.48, P= 0.006). After treatment, the average DBP and SBP at 24 h, day and night in group B were lower than those in group A (tDBP =6.154, 1.941, 2.099, tSBP =5.629, 2.518, 2.688, all P<0.05). After treatment, the coefficient of variation of blood pressure in group B was lower than that in group A (tDBP =1.812, 2.938, 2.598, tSBP =4.577, 2.938, 12.642, all P<0.05). After treatment, the morning blood pressure surge in group B was lower than that in group A (t=6.732, P<0.001). Conclusion The combined use of amlodipine and irbesartan in theevening has better control effect on blood pressure variability and morning blood pressure surge than the combined use of amlodipineand irbesartan in the morning. |
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