| 马赛,安峰,李立恒,等.癌胚抗原相关细胞黏附分子 6和增殖细胞核抗原在涎腺黏液表皮样癌中的表达及临床意义[J].安徽医药,2021,25(7):1369-1372. |
| 癌胚抗原相关细胞黏附分子 6和增殖细胞核抗原在涎腺黏液表皮样癌中的表达及临床意义 |
| Expression and clinical significance of CEACAM 6 and Ki-67 in mucoepidermoid carcinoma of salivary glands |
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| DOI：10.3969/j.issn.1009-6469.2021.07.024 |
| 中文关键词: 涎腺肿瘤 癌胚抗原类 Ki-67抗原 增殖 |
| 英文关键词: Salivary gland neoplasms Carcinoembryonic antigens Ki-67 antigen Proliferation |
| 基金项目:河北省重点研发计划自筹项目( 172777144)；张家口市 2018年度科学技术研究与发展计划资助项目( 1811032D-7)； |
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| 中文摘要: |
| 目的研究癌胚抗原相关细胞黏附分子 6(CEACAM 6)与增殖细胞核抗原( Ki-67)在不同病理特征的涎腺黏液表皮样癌( MEC)中的表达情况及临床意义。方法应用免疫组织化学 SP法检测 2005年 6月至 2014年 10月河北北方学院附属第一医院病理科留存的 50例不同临床病理特征的涎腺 MEC组织、 30例正常涎腺组织与 30例多形性腺瘤( SPA)中 CEACAM 6与 Ki67的表达情况。结果 CEACAM 6、Ki-67在涎腺 MEC组中阳性表达率分别为 62.00%(31/50)、 56.00%(28/50)在涎腺 SPA组中分别为 33.33%(10/30)、 30.00%(9/30)，在正常涎腺组中分别为 20.00%(6/30)、 13.33%(4/30)，涎腺 MEC组显著，高于对照组(P<0.0167)；在不同病理特征的涎腺 MEC组间比较中， CEACAM 6、Ki-67在病理分级组、 TNM分期组、有无淋巴结转移组中的表达阳性率差异有统计学意义( P<0.05)，病理分级 Ⅲ组、 TNM分期 Ⅲ+Ⅳ组、有淋巴结转移组的阳性表达均分别高于病理分级 Ⅰ+Ⅱ级组、 TNM分期 Ⅰ+Ⅱ组、无淋巴结转移组，而在不同性别、年龄、部位组中 CEACAM 6、Ki-67表达阳性率差异无统计学意义(P>0.05)；在涎腺 MEC中 CEACAM 6与 Ki-67的表达呈正相关(rs=0.551，P<0.001)。结论在涎腺 MEC组织中 CEACAM 6可能是通过调控 Ki-67的表达来促进肿瘤组织的增殖。检测 CEACAM 6和 Ki-67可以为涎腺 MEC的诊断、治疗提供参考。 |
| 英文摘要: |
| Objective To sutdy the expression and clinical significance of carcinoembryonic antigen related adhesive molecular 6(CEACAM 6) and proliferating cell nuclear antigen Ki-67 in mucoepidermoid carcinoma of salivary glands.Methods The expression of CEACAM 6 and Ki-67 in 50 cases of MEC, 30 cases of SPA and 30 cases of normal tissues in the Department of Pathology of TheFirst Affiliated Hospital of Hebei North College from June 2005 to October 2014 were detected by immunohistochemical method. Therelationship between their expression and different clinical pathological features in MEC of salivary glands were analyzed.Results The positive expression rates of CEACAM 6 and Ki-67 were 62.00% (31/50) and 56.00% (28/50) in MEC tissues, 33.33% (10/30) and30.00% (9/30) in SPA tissues, 20.00% (6/30) and 13.33% (4/30) in normal tissues. The positive rates of CEACAM 6, Ki-67 were higher in MEC tissues than those in SPA tissues and normal tissues (P<0.0167). In the comparison of different pathological features of salivarygland MEC groups, the positive expressions of CEACAM 6 and Ki-67 were significant difference in the groups of differentpathologicalgrade level, different TNM stage and patients with or without lymph node metastasis, the difference was statistically significant (P< 0.05), pathological grade level Ⅲ patients, TNM stage Ⅲ+Ⅳ, and patients with lymph node metastasis were higher than those in pathological grade levelⅠ+Ⅱ patients, TNM stage Ⅰ+Ⅱ patients and patients without lymph node metastasis. There was no significant difference beween the positive expressions of CEACAM 6 and Ki-67 in the groups of different genders, ages and tumor sites (P>0.05). There was a positive correlation beween the positive expressions of CEACAM 6 and Ki-67 in MEC tissues (rs=0.551, P<0.001).Conclu? sion CEACAM 6 may promote the proliferation of MEC tissues by regulating the expression of Ki-67. Detecting the expressions of CEACAM 6 and Ki-67 could provide reference for the diagnosis and treatment of MEC of salivary glands. |
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