| 施星月,李胜利,刘峰林,等.阿司匹林对结直肠癌 4，5-二磷酸磷脂酰肌醇 3激酶基因突变病人生存获益的 Meta分析[J].安徽医药,2021,25(9):1697-1700. |
| 阿司匹林对结直肠癌 4，5-二磷酸磷脂酰肌醇 3激酶基因突变病人生存获益的 Meta分析 |
| Aspirin improves survival of patients with PIK3CA-mutated colorectal cancer: a meta-analysis |
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| DOI：10.3969/j.issn.1009-6469.2021.09.001 |
| 中文关键词: 结直肠肿瘤 阿司匹林 4，5-二磷酸磷脂酰肌醇 3激酶(PIK3CA)突变 预后 Meta分析 |
| 英文关键词: Colorectal neoplasms Aspirin PIK3CA mutation Prognosis Meta-analysis |
| 基金项目:江苏省“六大人才高峰” B类项目( 2014-WSW-040)；江苏省科教强卫创新团队( CXTDA2017034) |
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| 中文摘要: |
| 目的采用 Meta分析探讨服用阿司匹林是否改善结直肠癌 4，5-二磷酸磷脂酰肌醇 3激酶( PIK3CA)突变病人的预后。方法计算机检索 2000年 3月至 2019年 5月万方数据库、中国知网( CNKI)、维普数据库(VIP)、PubMed、Embase和 Cochrane等数据库中关于服用阿司匹林与结直肠癌 PIK3CA突变病人预后关系的文献，提取总体生存的预后相关结果进行效应量的合并，对纳入的数据进行分析、发表偏倚分析等。采用 StataSE12.0软件对纳入的文献进行 Meta分析。结果共纳入文献 6篇，共计结直肠癌病人 5 574例。服用阿司匹林可提高结直肠癌 PIK3CA突变型病人的总生存率( HR=0.67，95%CI:0.48~0.93)；而 PIK3CA野生型病人并没有显著的生存获益( HR=0.97，95%CI:0.66~1.44)。结论服用阿司匹林可改善结直肠癌 PIK3CA突变病人的预后生存。 |
| 英文摘要: |
| Objective To explore whether aspirin use improves the prognosis of patients with PIK3CA-mutated colorectal cancer (CRC)by meta-analysis.Methods , Literature about the relationship between aspirin use and the prognosis of patients with PIK3CAmutated colorectal cancer published from March 2000 to May 2019 was retrieved from Wanfang database, CNKI, VIP, PubMed, Em‐base and Cochrane. Prognostic outcomes related to overall survival were extracted and the effect size was combined. Data included wereanalyzed, including published bias analysis, and so on. StataSE12.0 software was used for Meta-analysis of the included literature.Re? sults A total of 6 papers were included, with a total of 5 574 patients. Taking aspirin after diagnosis could improve the overall survivalrate of patients with PIK3CA-mutated colorectal cancer (HR=0.67,95%CI: 0.48-0.93). Yet there was no significant survival benefit in wild-type PIK3CA patients (HR=0.97,95%CI: 0.66-1.44) .Conclusion Taking aspirin after diagnosis can improve the prognostic survival of patients with PIK3CA-mutated colorectal cancer. |
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