| 李华,徐鹏,赵艳,等.急性一氧化碳中毒病人血清氨基末端脑钠肽前体、心肌肌钙蛋白 I水平与预后的关系[J].安徽医药,2021,25(9):1866-1870. |
| 急性一氧化碳中毒病人血清氨基末端脑钠肽前体、心肌肌钙蛋白 I水平与预后的关系 |
| Serum N terminal pro B type natriuretic peptide and cardiac troponin I levels in patients with acute carbon monoxide poisoning and their relationships with prognosis |
| |
| DOI：10.3969/j.issn.1009-6469.2021.09.040 |
| 中文关键词: 一氧化碳中毒 氨基末端脑钠肽前体 心肌肌钙蛋白 I 预后 |
| 英文关键词: Carbon monoxide poisoning N terminal pro B type natriuretic peptide Cardiac troponin I Prognosis |
| 基金项目: |
|
| 摘要点击次数: 1254 |
| 全文下载次数: 478 |
| 中文摘要: |
| 目的检测急性一氧化碳中毒( ACOP)病人血清氨基末端脑钠肽前体( NT-proBNP)、心肌肌钙蛋白 I(cTnI)水平，分析其与 ACOP病人预后关系。方法选择 78例 2016年 6月至 2018年 12月湖北医药学院附属襄阳市第一人民医院收治的 ACOP病人，另选取 78例同期在该院体检显示健康者为健康对照组。使用全自动荧光免疫分析仪检测 ACOP病人血清 NT-proBNP、 cTnI水平，分析其与 ACOP病人临床病理特征关系及影响 ACOP病人预后危险因素。结果就诊时轻度组、中度组、重度组病人血清 NT-proBNP、cTnI水平依次显著升高( P<0.05)，重度组病人在入院第 1、3、7、14天后血清 NT-proBNP、cTnI水平均显著高于轻度、中度组病人(均 P<0.05)。预后良好组与预后不良组相比，中毒时间、急性生理学和慢性健康状况评价 Ⅱ(APACHEⅡ)评分、心肌损伤比例、肌酸激酶水平、肌酸激酶同工酶( CKMB)水平、天冬氨酸氨基转移酶(AST)水平及缺血性心电图改变比例均有显著性差异(均 P<0.05)。预后不良组初始血清 NT-proBNP水平、 cTnI水平分别为( 322.83±101.64)ng/L、(1.47±0.38)μg/L，均显著高于预后良好组的( 96.59±30.07)ng/L、(0.22±0.06)μg/L(均 P<0.05)。 ACOP病人血清 NT-proBNP水平与 APACHEⅡ评分、肌酸激酶水平、 CKMB水平呈正相关(均 P<0.05)血清 cTnI水平与 APACHEⅡ评分、肌酸激酶水平呈正相关(均 P<0.05)。高肌酸激酶水平、高初始 NT-proBNP水平、高初始 cTnI水，平是预测 ACOP病人不良预后的危险因素( P<0.05)。结论血清 NTproBNP、cTnI水平随患病 ACOP病人疾病程度加深而升高，且在治疗后 14 d内均有不同程度降低，与 ACOP患病程度和 ACOP病人预后有关，可能为临床评估 ACOP患病程度、评估预后提供一定参考。 |
| 英文摘要: |
| Objective To detect the levels of serum N terminal pro B type natriuretic peptide (NT-proBNP) and cardiac troponin I(cTnI) levels in patients with acute carbon monoxide poisoning (ACOP) and to analyze their relationship with the prognosis of patients.Methods Seventy-eight patients with ACOP admitted to Xiangyang First People's Hospital Affiliated to Hubei Medical College fromJune 2016 to December 2018 were selected, and another 78 healthy persons were selected as healthy control group. Serum NT-proBNP and cTnI levels in ACOP patients were measured by automatic fluorescence immunoassay. The relationships between NT-proBNP, cTnIlevels and the clinicopathological characteristics of ACOP patients and the risk factors affecting the prognosis of ACOP patients wereanalyzed.Results Serum NT-proBNP and cTnI levels in mild group, moderate group and severe group increased significantly in turn at medical visit (P < 0.05). The levels of serum NT-proBNP and cTnI in the severe group were significantly higher than those in themild and moderate groups on the 1st, 3rd, 7th and 14th days after admission (P < 0.05). There were significant differences in poisoning time, acute physiology and chronic health evaluation Ⅱ (APACHE-Ⅱ) score, myocardial damage ratio, the levels of creatine kinase,creatine kinase isoenzyme (CKMB), and aspartate aminotransferase (AST) and ischemic electrocardiogram changes ratio between thegood prognosis group and the poor prognosis group (all P < 0.05). The initial serum NT-proBNP and cTnI levels in poor prognosis groupwere (322.83±101.64) ng/L and (1.47±0.38) μg/L respectively, which were significantly higher than those in good prognosis group[(96.59±30.07) ng/L and (0.22±0.06) μg/L, P < 0.05]. Serum NT-proBNP level was positively correlated with APACHE-Ⅱ score, creatine kinase level and CKMB level in ACOP patients (all P < 0.05). Serum cTnI level in ACOP patients was positively correlated with APACHE-Ⅱ score and creatine kinase level (P < 0.05). High creatine kinase level, high initial NT-proBNP level and high initial cTnI level were risk factors for predicting adverse prognosis of ACOP patients (P < 0.05).Conclusion Serum NT-proBNP and cTnI levelsincrease with the severity of ACOP and decrease in varying degrees within 14 days after treatment, which is related to the severity of ACOP and the prognosis of ACOP patients, and may provide reference for clinical evaluation of the severity of ACOP and prognosis. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
