| 刘建震,王永军,吕培,等.前列地尔联合羟苯磺酸钙对早期糖尿病肾病病人炎症损伤及肾功能的影响[J].安徽医药,2021,25(9):1871-1874. |
| 前列地尔联合羟苯磺酸钙对早期糖尿病肾病病人炎症损伤及肾功能的影响 |
| Effect of Alprostadil combined with Calcium Dobesilate on inflammatory injury and renal function in patients with early diabetic nephropathy |
| |
| DOI：10.3969/j.issn.1009-6469.2021.09.041 |
| 中文关键词: 糖尿病肾病 前列地尔 羟苯磺酸钙 炎症损伤 肾功能 |
| 英文关键词: Diabetic nephropathy Alprostadil Calcium Dobesilate Inflammatory injury Renal function |
| 基金项目:河北省 2018年度医学科学研究重点课题计划项目( 20180677) |
|
| 摘要点击次数: 1370 |
| 全文下载次数: 499 |
| 中文摘要: |
| 目的观察前列地尔联合羟苯磺酸钙对早期糖尿病肾病( DN)病人炎症损伤及肾功能的影响。方法选择 2017年 2月至 2019年 2月河北省胸科医院治疗的 DN病人 114例，应用随机数字表法分为两组，均 57例。对照组接受前列地尔( 10微克 /次， 1次/天)静脉注射治疗，观察组在对照组疗法基础上接受羟苯磺酸钙(0.5克/次， 3次/天)联合治疗。均连续治疗 3个月。观察两组临床疗效、治疗前后炎症损伤指标［超敏 C反应蛋白( hs-CRP)、白细胞介素 -6(IL-6)、肿瘤坏死因子 -α(TNF-α)］及肾功能指标［24 h尿蛋白排泄率( UAER)、 β2-微球蛋白( β2-MG)］、不良反应。结果观察组总有效率( 94.74%)较对照组( 78.95%)高( P<0.05)；治疗前两组 hs-CRP、IL-6、TNF-α、UAER、β2-MG水平对比，差异无统计学意义( P>0.05)；治疗后观察组 hs-CRP(6.02±1.59)mg/L、IL-6(13.16±3.59)ng/L、TNF-α(24.69±10.19)ng/L、UAER(60.08±12.46)μg/min、β2-MG(1.32±0.36)mg/L水平较对照组( 10.98±1.87)mg/L、(22.01±4.10)ng/L、(35.74±13.08)ng/L、(87.63±16.37)μg/min、(2.15±0.44)mg/L低( P<0.05)；观察组、对照组不良反应发生率( 3.51%、8.77%)相比，差异无统计学意义( P>0.05)。结论早期 DN病人接受前列地尔、羟苯磺酸钙联合治疗的安全性、有效性较高，有利于减轻炎症损伤，增强病人肾功能。 |
| 英文摘要: |
| Objective To observe the effects of Alprostadil combined with Calcium Dobesilate on inflammatory injury and renalfunction in patients with early diabetic nephropathy (DN).Methods A total of 114 patients with DN who were treated in Hebei ChestHospital from February 2017 to February 2019 were selected and divided into two groups using a random number table method, with 57cases in each group. The control group received intravenous injection of alprostadil (10 micrograms/time, once/day), and the observation group received calcium dobesilate (0.5 g/time, 3 times/day) combined treatment on the basis of the control group. All were treatedcontinuously for 3 months. Observe the clinical efficacy of the two groups, indicators of inflammation damage before and after treatment[high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α)] and renal function indexes [24 h urine protein excretion rate (UAER), β2-microglobulin (β2-MG)], adverse reactions.Results The total response rate in the observationgroup (94.74%) was higher than that in the control group (78.95%), and the difference was statistically significant (P<0.05). Before treatment, the levels of hs-CRP, IL-6, TNF-α, UAER, β2-MG showed no significant difference between the two groups (P>0.05). After treatment, the levels of hs-CRP, IL-6, TNF-α, UAER, β2-MG in the observation group were (6.02±1.59) mg/L, (13.16±3.59) ng/L,(24.69±10.19) ng/L, (60.08±12.46) μg/min, and (1.32±0.36) mg/L, which were higher than those in the control group, which were(10.98±1.87) mg/L, (22.01±4.10) ng/L, (35.74 ±13.08) ng/L, (87.63±16.37) μg/min and (2.15±0.44) mg/L (P<0.05). The incidence ofadverse reactions (3.51% in the observation group and 8.77% in the control group) showed no statistically significant difference (P> 0.05).Conclusion For patients with early DN, Alprostadil combined with Calcium Dobesilate is safe and effective, which can help reduce the inflammatory injury and improve their renal function. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
