| 陶俊,周漫,李艳.2型糖尿病病人估算肾小球滤过率与糖尿病视网膜病变的相关性研究[J].安徽医药,2021,25(10):1954-1957. |
| 2型糖尿病病人估算肾小球滤过率与糖尿病视网膜病变的相关性研究 |
| Correlation between estimated glomerular filtration rate and diabetic retinopathy in type 2 diabetic patients |
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| DOI：10.3969/j.issn.1009-6469.2021.10.011 |
| 中文关键词: 糖尿病， 2型 糖尿病视网膜病变 估算肾小球滤过率 危险因素 |
| 英文关键词: Diabetes mellitus,type 2 Diabetic retinopathy Estimate glomerular filtration rate Risk factors |
| 基金项目:国家自然科学基金( 81772265) |
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| 中文摘要: |
| 目的探讨 2型糖尿病病人估算肾小球滤过率( eGFR)与糖尿病视网膜病变( DR)的相关性。方法 2018年 10月至 2019年 4月武汉大学人民医院内分泌科收治的 204例 2型糖尿病病人，根据其是否并发糖尿病视网膜病变，将其分为无视网膜病变( NDR)组 88例，视网膜病变( DR)组 116例。分别对两组研究对象的预估肾小球滤过率( eGFR)、糖化血红蛋白( HbA1c)、空腹血糖( FPG)等生化指标进行检测，对比分析两组研究对象的检测水平。 Spearman相关性分析分析 eGFR与 DR危险因素的相关性。 logistic回归分析 eGFR与 DR发生的相关性。结果 DR组 HbA1c为 9.65(7.93，11.15)mmol/L、尿素( urea)为 6.12(4.73，7.66)mmol/L、血清肌酐( Scr)为 62.00(53.00，93.50)μmol/L、尿酸( UA)为 360.00(309.25，429.50)μmol/L、收缩压( SBP)为(133.19±18.46)mmHg，较 NDR组( 8.19±1.70)mmol/L、(5.30±1.39)mmol/L、(57.64±15.40)μmol/L、304.00(261.00，347.50)μmol/ L、(126.98±13.90)mmHg显著升高； DR组 ALB为 40.60(38.50，42.50)g/L、eGFR为 96.79(72.17，107.45)mL/min较 NDR组白蛋白 41.60(39.60，44.60)g/L、(107.67±13.97)mL/min显著降低，均差异有统计学意义( P<0.05)。 Spearman相关性分析显示， eGFR与年龄( rs=?0.422)、 HbA1c(rs=?0.336)及 SBP(rs=?0.190)呈显著的负相关( P<0.05)。多因素 logistic回归分析显示 eGFR、HbA1c、 ALB、urea、UA是 DR发生的危险因素( P<0.05)。结论 eGFR水平降低是 2型糖尿病病人发生视网膜病变的危险因素。 |
| 英文摘要: |
| Objective To investigate the correlation between estimated glomerular filtration rate (eGFR) and diabetic retinopathy(DR) in type 2 diabetes patients.Method Two hundred and four patients with type 2 diabetes admitted to Department of Endocrinology, Renmin hospital of Wuhan university from October 2018 to April 2019 were assigned into the without diabetic retinopathy group(NDR group, 88 cases) and the diabetic retinopathy group (DR group, 116 cases) according to whether they were complicated with diabetic retinopathy or not. Estimated glomerular filtration rate (eGFR), glycosylated hemoglobin (HbA1c), fasting plasma glucose (FPG)and other serum biochemical parameters were given to research objects in two groups. The detection levels of research objects in twogroups were compared. Spearman analysis was performed to investigate the correlations between eGFR and the risk factors of DR. Logistic regression was performed to investigate the risk factor of DR.Results The levels of HbA1c [9.65 (7.93, 11.15) mmol/L], urea[6.12 (4.73, 7.66) mmol/L], serum creatinine (Scr) [62.00 (53.00, 93.50) μmol/L], uric acid (UA) [360.00 (309.25, 429.50) μmol/L],systolic blood pressure (SBP) [(133.19±18.46) mmHg] in DR group were significantly increased than the levels of HbA1c [(8.19±1.70)mmol/L], urea [(5.30±1.39) mmol/L], Scr [(57.64±15.40) μmol/L], UA [304.00 (261.00, 347.50) μmol/L], SBP [(126.98±13.90) mmHg]in NDR group. The levels of albumin (ALB) [40.60 (38.50, 42.50)g/L], eGFR [96.79 (72.17, 107.45) mL/min] in the DR group were significantly reduced than the levels of ALB [41.60 (39.60,44.60) g/L], eGFR [(107.67±13.97) mL/min] in NDR group, and the differ ence was statistically significant (P<0.05). Spearman correlation analysis showed that eGFR was negatively correlated with age (rs=?0.422), HbA1c (rs=?0.336), SBP (rs=?0.190) (P<0.05). Logistic regression analysis showed that eGFR, HbA1c, ALB, urea, UA were risk factors for the development of DR (P<0.05).Conclusion Decreased eGFR levels may be a risk factor for DR in patients with type 2 diabetes. |
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