| 潘荣,罗兵,孙敏捷,等.单核细胞与淋巴细胞比值与社区获得性肺炎严重程度评分的关系[J].安徽医药,2021,25(10):1962-1966. |
| 单核细胞与淋巴细胞比值与社区获得性肺炎严重程度评分的关系 |
| Relationship between monocyte to lymphocyte ratio and score for disease severity in patients with community-acquired pneumonia |
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| DOI：10.3969/j.issn.1009-6469.2021.10.013 |
| 中文关键词: 社区获得性感染 肺炎 单核细胞与淋巴细胞比值 CAP严重程度 纤维蛋白原 超敏 C反应蛋白 |
| 英文关键词: Community-acquired infections Pneumonia Monocyte to lymphocyte ratio Severity of community-acquired pneumonia Fibrinogen Hypersensitive C-reactive protein |
| 基金项目:国家自然科学基金( 81803938)；安徽省教育厅高校科学研究重点项目( KJ2019A1099) |
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| 中文摘要: |
| 目的探讨单核细胞与淋巴细胞比值( MLR)和社区获得性肺炎严重程度评分( CURB-65)之间的关系。方法回顾性分析安徽省第二人民医院 2018年 1月至 2019年 4月收治的 82例社区获得性肺炎( CAP)病人、 40例健康受试者的临床资料和实验室指标结果，根据 CURB-65评分系统将 82例 CAP分为低危 CAP组 42例和中高危 CAP组 40例。采用希森美康全自动血细胞分析仪 XT-4000i和全自动凝血分析仪 CS-5100、日立全自动生化仪 008AS检测各项实验室指标，采用回归和相关分析 MLR与白细胞计数( WBC)、超敏 C反应蛋白( hs-CRP)、纤维蛋白原( FIB)和 CURB-65评分的相关性，采用 ROC曲线比较 MLR、单核细胞计数( M)曲线下面积( AUC)评估其在预测 CAP是否严重诊断中的预测效能。结果研究发现 CAP病人的 MLR(0.67±0.63)高于健康对照组( 0.17±0.05)(P<0.05)；低危 CAP病人的 MLR(0.45±0.29)高于对照组( 0.17±0.05)(P<0.05)，与低危 CAP病人 MLR(0.45±0.29)相比，中高危 CAP病人的 MLR(0.90±0.79)进一步升高( P<0.05)； MLR与 WBC、hs-CRP、FIB及 CURB65评分呈正相关( P<0.05)；预测 CAP严重的 ROC曲线中， MLR的 AUC大于 M；MLR与 CAP严重风险提高相关( OR=23.206， 95%CI:1.339~402.275，P=0.031)；结论 MLR可能是评估 CAP严重程度的新的炎症标志物，其快速、廉价、简便，值得临床推广应用。 |
| 英文摘要: |
| Objective To investigate the relationship between monocyte to lymphocyte ratio (MLR) and community-acquired pneumonia severity score (CURB-65).Methods Clinical data and laboratory indicators of 82 patients with community-acquired pneumonia(CAP) and 40 healthy subjects admitted to Anhui No.2 Provincial People's Hospital from January 2018 to April 2019 were analyzed retrospectively. Eighty-two patients with CAP were assigned into two groups according to the CURB-65 scoring system: the low-risk CAP group(42 cases) and the medium-high-risk CAP group(40 cases). The automatic blood cell analyzer XT-4000i and automatic blood coagulation analyzer CS-5100 of SYSMEX, the automatic biochemical analyzer 008AS of HITACHI were employed to detect laboratory indicators. Regression and correlation analysis were used to analyze the correlation among MLR, WBC, hs-CRP, FIB and CURB-65. The predictive efficacy of MLR, M in the diagnosis of severity of CAP was evaluated by comparing the area under the curve (AUC) of ROCcurve.Results MLR (0.67±0.63) in patients with CAP were higher than that in the normal control group (0.17±0.05) (P<0.05). MLR (0.45±0.29) in patients with low-risk CAP were higher than that in the normal control group (0.17±0.05) (P<0.05). MLR (0.90±0.79) in patients with medium-high-risk CAP were further increased than that in patients with low-risk CAP (0.45±0.29) (P<0.05). MLR were positively correlated with WBC, hs-CRP, FIB and CURB-65 scores (P<0.05). In the receiver operating characteristic (ROC) curve forpredicting severe CAP, the area under the curve (AUC) of MLR was greater than M. MLR was also an independent risk factor for severeCAP (OR=23.206, 95%CI: 1.339-402.275, P=0.031).Conclusion MLR, which may be a inflammatory markers that can be used toevaluate the severity of CAP, are rapidly detected, inexpensive and simple, and worthy of clinical application. |
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