| 王新栋,李德元,曹贵章.腹腔镜 D2根治术对局部进展期远端胃癌病人血清 CA724、胃蛋白酶原及胃泌素 -17的影响[J].安徽医药,2021,25(10):2048-2051. |
| 腹腔镜 D2根治术对局部进展期远端胃癌病人血清 CA724、胃蛋白酶原及胃泌素 -17的影响 |
| Effect of laparoscopic D2 radical surgery on serum CA724, pepsinogen and gastrin-17 in patients with locally advanced distal gastric cancer |
| |
| DOI：10.3969/j.issn.1009-6469.2021.10.032 |
| 中文关键词: 胃肿瘤 胃切除术 腹腔镜 D2根治术 糖类抗原 724 胃蛋白酶原 胃泌素 -17 /5， |
| 英文关键词: Stomach neoplasms Gastrectomy Locally advanced distal gastric cancer CA724 Pepsinogen Gastrin-17 |
| 基金项目: |
|
| 摘要点击次数: 1725 |
| 全文下载次数: 663 |
| 中文摘要: |
| 目的腹腔镜 D2根治术(LD2RS)对局部进展期远端胃癌(LADGC)病人血清糖类抗原( CA)724、胃蛋白酶原( PG)及胃泌素 -17(G-17)的影响。方法纳入 2013年 1月至 2015年 12月入住青海省交通医院的 LADGC病人 116例，依照随机数字表法分为腹腔镜组( n=58)与开腹组( n=58)。开腹组行开腹胃癌 D2根治术( OD2RS)治疗，腹腔镜组行 LD2RS治疗。观察两组手术及术后恢复指标，术前、术后 7d血清 CA724、PG、G-17水平。术后并发症及术后 3年生存情况等指标。结果腹腔镜组术中失血量( 203.58±21.37)mL、切口长度( 6.18±0.64)cm、术后排气时间( 2.84±0.29)d、住院时间( 10.95±1.14)d均短于开腹组( 386.54±40.27)mL、(18.97±1.98)cm、(4.62±0.48)d、(16.84±1.73)d，P<0.05。腹腔镜组手术时间( 279.54±29.96)min长于开腹组( 213.64±22.97)min(P<0.05)。术后 7d，开腹组 CA724(25.92±2.75)U/mL、PGⅠ(78.83±7.92)ng/mL、PGⅡ(18.95±1.90)ng/mL及 G-17 |
| 英文摘要: |
| Objective To study the effect of laparoscopic D2 radical surgery on serum CA724, pepsinogen (PG) and gastrin-17 (G17) in patients with locally advanced distal gastric cancer (LADGC).Methods One hundred and sixteen patients with LADGC admitted to Qinghai Provincial Traffic Hospital from January 2013 to December 2015 were selected and assigned into laparoscopic group (n= 58) and open group (n=58) according to the random number table method. The open group received OD2RS treatment, while the laparoscopic group received LD2RS treatment. The indexes of operation and postoperative recovery including serum CA724, PG, G-17 levels before and 7 days after operation were observed, and postoperative complications and 3-year survival after operation were observed.Re? sults The blood loss (203.58±21.37) mL, incision length (6.18±0.64) cm, postoperative exhaust time (2.84±0.29) d and hospitalizationtime (10.95±1.14) d in laparoscopic group were shorter than the blood loss (386.54±40.27) mL, incision length (18.97±1.98), postoperative exhaust time (4.62±0.48) d and hospitalization time (16.84±1.73) d in open group (P<0.05). The operation time (279.54±29.96)min in laparoscopic group was longer than the operation time (213.64±22.97) min in open group (P<0.05). 7 days after surgery, the levels of CA724 (25.92±2.75) U/mL, PGⅠ(78.83±7.92) ng/mL, PGⅡ(18.95±1.90) ng/mL and G-17 (62.95±6.33) ng/mL in the laparoscopy group were significantly higher than the levels of CA724(26.75±2.82)U/mL, PGⅠ(76.64±7.81) ng/mL, PGⅡ(19.06±1.96) ng/mLand G-17 (64.84±6.59) ng/mL in the operation time, there was no significant difference (P>0.05). The incidence of postoperative complications (6.90%) in laparoscopic group was lower than that in open group (22.41%) (P<0.05). There was no significant difference in the 3-year disease-free survival rate (31.03%) and overall survival rate (39.65%) between the laparoscopic group and the open group(34.48%, 20/58) and the overall survival rate (43.10%, 25/58) (P>0.05).Conclusion LD2RS can effectively remove CA724, PGⅠ, PG Ⅱ and G-17 after treatment of LADGC with little trauma and rapid recovery. The incidence of complications after operation is low, andit can achieve the same curative effect as OD2RS. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
