| 周晶晶,李东风,李时慧.2型糖尿病周围神经病变病人血清 25-羟维生素 D与焦虑、抑郁的相关性研究[J].安徽医药,2021,25(12):2393-2397. |
| 2型糖尿病周围神经病变病人血清 25-羟维生素 D与焦虑、抑郁的相关性研究 |
| Correlation between serum vitamin D and anxiety and depression in type 2 diabetic patients with peripheral neuropathy |
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| DOI：10.3969/j.issn.1009-6469.2021.12.015 |
| 中文关键词: 糖尿病神经病变 糖尿病， 2型 25-羟维生素 D 焦虑 抑郁 组(1，25(OH)D，析两.0， |
| 英文关键词: Diabetic neuropathies Diabetes mellitus, type 2 25-hydroxyvitamin D Anxiety Depression |
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| 中文摘要: |
| 目的探讨 25-羟维生素 D［25(OH)D］与 2型糖尿病周围神经病变( DPN)病人焦虑、抑郁的关系。方法选取 2017年 12月至 2019年 12月入住皖西卫生职业学院附属医院(六安市第二人民医院)内分泌科的 2型糖尿病病人 202例，将病人分为 |
| 英文摘要: |
| Objective To explore the relationship between 25-hydroxyvitamin D [25(OH)D] and anxiety and depression in patients with diabetic peripheral neuropathy (DPN).Methods A total of 202 T2DM patients admitted to Department of Endocrinology of The Affiliated Hospital of West Anhui Health Vocational College (Lu′an Second People′s Hospital) between December 2017 and December 2019 were enrolled. All patients were assigned into DPN group (n=120) and NDPN group (patients without peripheral neuropathy, n=82); according to the level of serum 25(OH)D, the DPN group was further divided into 25 (OH) D deficiency group (<50 nmol/L) and non-deficiency group (≥50 nmol/L). Serum 25 (OH) D was measured by electrochemiluminescence. The Hamilton Anxiety (HAMA) Scale and the Hamilton Depression (HAMD) Scale were used to evaluate the anxiety and depression of the patients in DPN group. Clini. cal and laboratory data were collected and compared between the two groups. The relationship between 25(OH)D and HAMA score and HAMD score was analyzed for patients in DPN group. Logistic regression analysis was employed to identity risk factors of depression in DPN patients. ROC (receiver operating characteristic) curve was applied to determine the value of 25(OH)D in the diagnosis of depres.sion in DPN patients.Results The HAMA and HAMD scores of DPN group [(10.18 5.45) and (23.67 13.46)] were significantly higher than those of NDPN group [(8.37 4.35) and (16.82 8.25)] (P<0.05). As compared with NDPN group, 25(OH)D level was obviously lower in DPN group (P<0.05). For patients in DPN group, the HAMD score of 25(OH)D deficiency group was significantly higher than that of non-deficiency group [(25.47±13.16) vs. (18.72±13.21), P<0.05)]. The level of 25 (OH) D was negatively correlated with HAMD score (r=.0.327,P<0.001). There was no statistically significant difference in HAMA score between the two groups (P>0.05) and no obvious correlation was found between the level of 25(OH)D and HAMA score. Logistic regression analysis indicated that 25(OH)D was an inde.pendent risk factor of depression in DPN group (P<0.05). ROC curve analysis indicated that the optimal cut-off point of 25(OH)D for DPN with depression was 43 nmol/L. The sensitivity and specificity were 64.1% and 82.1%, respectively.Conclusions Serum 25(OH) D was significantly decreased in T2DM patients with DPN, and involved in the pathogenesis of depression in DPN patients, but was not related to anxiety. 25(OH)D can be used as a serum marker for the diagnosis of depression in DPN patients. |
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