| 王淑辉,刘丽波,孔学哲.河北省承德地区大肠息肉发生的相关因素调查研究[J].安徽医药,2022,26(1):35-39. |
| 河北省承德地区大肠息肉发生的相关因素调查研究 |
| Investigation on the related factors of colorectal polyps in Chengde area of Hebei Province |
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| DOI：10.3969/j.issn.1009-6469.2022.01.008 |
| 中文关键词: 结肠息肉 流行病学特征 病理类型 癌变率 横断面研究 河北省承德 |
| 英文关键词: Colonic polyps Epidemiological characteristics Pathological type Cancer rate Cross-sectional studies Chengde,Hebei Province |
| 基金项目:承德市科技支撑计划项目( 201803269) |
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| 中文摘要: |
| 目的调查研究河北省承德地区大肠息肉发生的影响因素。方法采用随机抽样法向 2015年 1月至 2018年 10月于中国人民解放军联勤保障部队第九八一医院进行结肠镜检查的 3 008例人员发放大肠息肉调查问卷，严格按照质控标准回收问卷，统计问卷回收率、大肠息肉检出情况、流行病学特征，并根据肠镜检查结果，将伴有大肠息肉病人作为息肉组( n=532)、将无异常的病人作为对照组( n=2 464)，进而再根据癌变情况进行分组。比较两组临床资料，分别采用 logistic多元回归进行大肠息肉及癌变发生的影响因素分析，统计不同息肉病理类型癌变率。结果共回收 2 996份有效问卷，其中 532例发生大肠息肉，发生率为 17.76%，男女比例为 1.4∶1；高发年龄范围为 >40～60岁，占比 48.12%，34.77%病人伴有临床症状，直肠为高发部位( 31.11%)，腺瘤性息肉最为常见，占 57.96%，息肉长径多介于 5～10 mm，占比 28.75%。大腰围、幽门螺旋杆菌感染、喜食高脂饮食、尿酸 >420 μmol/L、饮酒史、脂肪肝、胆结石、高脂血症、糖尿病是大肠息肉发生的危险影响因素(P<0.05，OR>1)，喜食高纤维食物是大肠息肉发生的保护影响因素( P<0.05，OR<1)；幽门螺旋杆菌感染、喜食高脂饮食是大肠息肉病人发生癌变的危险影响因素( P<0.05，OR>1)；腺瘤性息肉癌变率高于其他病理类型( P<0.05)。结论河北省承德地区大肠息肉的发生与多种因素相关，高发年龄范围为 >40～60岁，高发部位为直肠、乙状结肠，常见病理类型为腺瘤性息肉，且大肠息肉发生的相关因素中，幽门螺旋杆菌感染、喜食高脂饮食与大肠癌发病呈正相关。 |
| 英文摘要: |
| Objective To investigate the related factors of colorectal polyps in Chengde, Hebei Province.Methods Questionnairewas distributed to 3 008 patients who had colonoscopy in No. 981 Hospital of The Joint Service Support Force of The People's Libera-tion Army from January 2015 to October 2018 by random sampling. The questionnaire was recovered strictly according to the qualitycontrol standard. The recovery rate, detection and epidemiological characteristics of the questionnaire were statistically analyzed. Ac-cording to the results of colonoscopy, patients with colonoscopy were treated as polyp group (n = 532), and there was no abnormality Pa-tients served as control group (n = 2 464), and then were assigned into groups according to the canceration. Compared with the clinicaldata of the two groups, logistic multiple regression was used to analyze the influencing factors of colorectal polyps and canceration, andthe canceration rate of different pathological types of polyps was counted.Results 2 996 valid questionnaires were collected, 532 cas-es of colorectal polyps occurred, the incidence was 17.76%, the ratio of male to female was 1.4:1; the age range of high incidence was >40-60 years old, accounting for 48.12%, 34.77% of patients had clinical symptoms, the rectum was the high incidence area (31.11%),the adenomatous polyps were the most common, accounting for 57.96%, and the polyp diameter was more than 5-10 mm, accounting for28.75%. Large waist circumference, Helicobacter pylori infection, high fat diet, uric acid > 420 μmol / L, drinking history, fatty liver,gallstone, hyperlipidemia, diabetes mellitus were the risk factors of colorectal polyps (P<0.05, OR>1). The preference for high-fiber food was the risk factor of colorectal polyp canceration (P<0.05, OR>1); Helicobacter pylori infection and the preference for high-fat di-et are the risk factors for canceration of colorectal polyps patients (P<0.05, OR>1); the canceration rate of adenomatous polyp was high-er than that of other pathological types (P < 0.05).Conclusions The occurrence of colorectal polyps in Chengde area of Hebei Prov-ince is related to many factors. The high-risk age is 41-60 years old. The high-incidence site is rectum and sigmoid colon. The commonpathological type is adenomatous polyp. Among the related factors of colorectal polyps, pyloric helix Bacterial infection, eating high-fat diet is positively correlated with the incidence of colorectal cancer. |
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