| 柴小娟,原新慧,李宇宁,等.肠道菌群与川崎病[J].安徽医药,2022,26(2):213-216. |
| 肠道菌群与川崎病 |
| Gut microbiota and Kawasaki disease |
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| DOI：10.3969/j.issn.1009-6469.2022.02.001 |
| 中文关键词: 川崎病 肠道菌群 发病机制 菌群干预 |
| 英文关键词: Kawasaki disease Gut microbiota Pathogenesis |
| 基金项目:甘肃省科技厅自然科学基金( 20JR5RA358)；甘肃省卫生行业科研计划资助( GSWSKY2017-12)；兰州市城关区科技计划项目( 2018-7-8) |
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| 中文摘要: |
| 川崎病(KD)是一种儿童急性发热性全身性中、小动脉炎，是儿童获得性心脏病最常见的原因，其主要特征为免疫紊乱和全身性血管炎。以婴幼儿多见，其病因及发病机制不明，与感染、遗传及环境因素相关。近年来研究表明， KD病人存在肠道菌群紊乱，导致了肠道屏障功能破坏和自身免疫激活。作者对 KD的肠道菌群研究做一综述，探讨菌群干预作为 KD防治新策略的应用价值。 |
| 英文摘要: |
| Kawasaki disease (KD) is a kind of acute febrile systemic arteritis in children. It is the most common cause of childhoodacquired heart disease and is characterized by immune disorders and systemic vasculitis. It is more common in infants and young chil.dren. It's etiology and pathogenesis are unknown, and are related to infection, genetic and environmental factors. Recent studies haveshown that KD patients have gut microbiota disorder, which leads to the destruction of gut barrier function and autoimmune activation.This article reviews the research on the gut microbiota of Kawasaki disease and discusses the application value of gut microbiota-relat. |
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