文章摘要
范伟光,孟娟,苏苗苗,等.人类免疫缺陷病毒感染者抗病毒治疗期间病毒载量与免疫学指标的关系[J].安徽医药,2022,26(2):257-260.
人类免疫缺陷病毒感染者抗病毒治疗期间病毒载量与免疫学指标的关系
Relationship between viral load and immunological indexes in HIV infected patients during antiviral therapy
  
DOI:10.3969/j.issn.1009-6469.2022.02.012
中文关键词: 获得性免疫缺陷综合征  人类免疫缺陷病毒  抗病毒治疗  病毒载量  免疫学指标
英文关键词: Acquired immunodeficiency syndrome  Human immunodeficiency virus  Antiviral therapy  Viral load Immuno. logical index
基金项目:保定市科技计划项目( 1951ZF007)
作者单位E-mail
范伟光 保定市人民医院检验科河北保定 071000  
孟娟 保定市人民医院感染科河北保定 071000  
苏苗苗 保定市人民医院感染科河北保定 071000  
王浩 保定市人民医院检验科河北保定 071000  
石鹏辉 保定市人民医院检验科河北保定 071000 285409022@qq.com 
张珍 保定市人民医院感染科河北保定 071000  
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中文摘要:
      目的探讨人类免疫缺陷病毒( HIV)感染者抗病毒治疗期间病毒载量(VL)与免疫学指标的关系。方法建立前瞻性研究队列,选取 2018年 1月至 2019年 1月在保定市人民医院治疗的确认为 HIV-1感染阳性的感染者 200例为研究对象,给予替诺福韦( TDF)+拉米夫定( 3TC)+依非韦伦( EFV)高效抗反转录病毒治疗( HAART)分别采集其用药前及用药后 1、3、6、12和 18月的血液样本,检测血液样本中 VL和免疫学指标 T淋巴细胞亚群 CD4+、CD8+以及免,疫球蛋白( IgG,IgA,IgM)分析治疗前后 VL、CD4+、CD8+、CD4+/CD8+、IgG、IgM、IgA变化,分析 VL与免疫学指标动力学变化趋势的相关性。结果与治疗前,(4.89±1.63)log/mL比较,用药后 1、3、6、12和 18月的 VL水平[(3.34±1.01)、(2.57±1.26)、(2.15±0.72)、(1.54±0.24)、(1.03±0.42)log/mL]随着治疗时间延长而下降( P<0.05)。与治疗前比较, CD4+、CD4+/CD8+比值在治疗时间段数值逐步上升( P<0.05)。 IgG、IgA水平在治疗时间段逐步下降( P<0.05)。经 Pearson相关性分析, VL与免疫学指标 CD4+、CD4+/CD8+呈负相关( r=.0.869,P<0.001;r =.0.794,P<0.001)与 CD8+无明显相关性( P>0.05); VL与 IgG、IgA水平均呈正相关( r=0.892,P<0.001;r=0.901,P<0.001)。 VL与 IgM水平无明关性( P>0.05)。结论抗病毒治疗可改善 HIV/AIDS免疫状态,部分细胞免疫及体液免疫指标动态变化显相,与 VL载量之间有相关性。
英文摘要:
      Objective To investigate the relationship between viral load(VL) and immunological indexes in HIV infected patients during antiviral therapy.Methods A prospective study cohort was established, and 200 HIV-1 positive patients who were treated inBaoding People's Hospital from January 2018 to January 2019 were selected as the research objects. They were treated with tenofovir(TDF) + lamivudine (3TC) + EFV (EFV) highly effective antiretroviral therapy (HAART). Blood samples were collected before and 1, 3,6, 12 and 18 months after treatment. The VL and immunological indexes of T lymphocyte subsets CD4+, CD8+ and immunoglobulin (IgG, IgA, IgM) in blood samples were detected. The changes of VL, CD4+, CD8+, CD4+ / CD8+, IgG, IgM and IgA before and after treat.ment were analyzed, and the correlation between VL and dynamic change trend of immunological indexes was analyzed.Results Com. pared with before treatment (4.89±1.63) log/mL, VL level was (3.34±1.01) , (2.57±1.26), (2.15±0.72), (1.54±0.24), (1.03±0.42) log/mL]at 1, 3, 6, 12 and 18 months after treatment, VL level decreased with the extension of treatment time (P < 0.05). Compared with before treatment, CD4+, CD4+ / CD8+ ratio increased gradually during the treatment period (P<0.05). The levels of IgG and IgA decreased grad. ually during the treatment period (P<0.05). According to Pearson correlation analysis, VL was negatively correlated with CD4+, CD4+ /CD8+ (r =.0.869, P<0.001; r =.0.794, P <0.001), but not with CD8+ (P>0.05); VL was positively correlated with the levels of IgG and IgA (r=0.892, P<0.001; r=0.901, P<0.001). There was no significant correlation between VL and IgM level (P>0.05).Conclusion An. tiviral therapy can improve the immune status of HIV/AIDS. There is a correlation between the dynamic changes of some cellular andhumoral immune indexes and VL.
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