| 李艺明,邓倩曦.酒精性肝炎病人血清微小核糖核酸 -182和微小核糖核酸 -30e检测及临床意义[J].安徽医药,2022,26(2):282-285. |
| 酒精性肝炎病人血清微小核糖核酸 -182和微小核糖核酸 -30e检测及临床意义 |
| Detection and clinical significance of serum mir-182 and mir-30e in patients with alcoholic hepatitis |
| |
| DOI：10.3969/j.issn.1009-6469.2022.02.018 |
| 中文关键词: 肝炎，酒精性 肝硬化，酒精性 微小核糖核酸 微小核糖核酸 -182 微小核糖核酸 -30e 临床意义 |
| 英文关键词: Hepatitis,alcoholic Liver cirrhosis,alcoholic MicroRNA MiR-182 MiR-30e Clinical significance |
| 基金项目: |
|
| 摘要点击次数: 1413 |
| 全文下载次数: 507 |
| 中文摘要: |
| 目的检测酒精性肝炎病人中血清微小核糖核酸( miR)-182和 miR-30e的水平，探讨其临床意义。方法选取 2018年 1月至 2019年 10月绵阳市第三人民医院收治的酒精性肝炎病人 98例为观察组，选取同时间段绵阳市第三人民医院体检中心体检的健康志愿者 89例为健康对照组。两组均采用荧光定量聚合酶链反应( FQ-PCR)检测外周血血清 miR-182和 miR-30e水平。比较两组及观察组中未并发酒精性肝硬化、并发酒精性肝硬化、酒精性肝硬化代偿期、酒精性肝硬化失代偿期病人血清 miR-182和 miR-30e水平。结果观察组血清 miR-182［( 0.21±0.04)比( 0.65±0.12)］和 miR-30e水平［( 0.41±0.08)比( 1.58± |
| 英文摘要: |
| Objective To detect the levels of serum microRNA (miR-182) and miR-30e in patients with alcoholic hepatitis and to explore their clinical significance.Methods Ninety-eight patients with alcoholic hepatitis who admitted to Mianyang Third People'sHospital from January 2018 to October 2019 were selected as the observation group, and 89 healthy volunteers who received physicalexamination at the Medical Examination Center of Mianyang Third People's Hospital during the same time period were selected ashealthy control group. The serum levels of miR-182 and miR-30e between the two groups were detected by fluorescence quantitative polymerase chain reaction (FQ-PCR). The serum levels of miR-182 and miR-30e in patients with non-complicated alcoholic cirrhosis,complicated alcoholic cirrhosis, alcoholic cirrhosis, and decompensated alcoholic cirrhosis were compared between the two groups andthe observation group.Results The average levels of miR-182 [(0.21±0.04) vs. (0.65±0.12)] and miR-30e [(0.41±0.08) vs. (1.58±0.25)] in the disease group were lower than those in the control group (P < 0.05). The serum levels of miR-182 [(0.13±0.03) vs. (0.24±0.05)] and miR-30e [(0.29±0.04) vs. (0.45±0.10)] in patients with alcoholic cirrhosis were lower than those in patients without alcoholic cirrho. sis (P < 0.05). The serum levels of miR-182 [(0.06±0.02) vs. (0.15±0.04)] and miR-30e [(0.13±0.03) vs. (0.35±0.05)] in patients with de.compensated alcoholic cirrhosis were lower than those in patients with decompensated alcoholic cirrhosis (P<0.05).Conclusion The serum levels of miR-182 and miR-30e are lower in patients with alcoholic hepatitis, especially in patients with alcoholic cirrhosis, andtheir levels of patients with decompensated liver cirrhosis are lower those in patients with compensated patients. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
