| 余超,李晟,曾永庆,等.基于 Oncomine数据库研究钙黏附蛋白 11基因在胃癌中的表达及意义[J].安徽医药,2022,26(2):365-368. |
| 基于 Oncomine数据库研究钙黏附蛋白 11基因在胃癌中的表达及意义 |
| Expression of CDH11 and its prognostic role in gastric cancer: analysis based on Oncomine database mining |
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| DOI：10.3969/j.issn.1009-6469.2022.02.035 |
| 中文关键词: 钙黏着糖蛋白类 胃肿瘤 Oncomine数据库 钙黏附蛋白 11 Kaplan-Meier plotter数据库 |
| 英文关键词: Cadherins Stomach neoplasms Oncomine database Cadherin11 Kaplan-Meier plotter database |
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| 摘要点击次数: 1067 |
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| 中文摘要: |
| 目的研究钙黏附蛋白 11(Cadherin11，CDH11)基因在胃癌中的表达并探讨其表达差异与预后的关系。方法通过 Oncomine数据库探索 CDH11在胃癌中的表达变化；应用在线数据库及分析工具 “the Kaplan Meier plotter”(KM plotter)数据库探索 CDH11在胃癌的预后评判价值。结果 Oncomine数据库中共有 445个涉及不同种类类型肿瘤的研究结果。其中有 66项研究结果关于 CDH11表达差异有统计学意义( P<0.05)59项研究结果显示 CDH11的表达增高， 7项研究结果显示 CDH11的表达降低。共有 85项研究， 8个数据子集涉及 CDH11在胃癌，和正常组织中的表达，共 478个样本，均显示 CDH11在胃癌中的表达较正常组织明显增高。另外， KM plotter数据库的分析显示 CDH11水平与胃癌病人的总生存时间呈负相关。结论与正常 |
| 英文摘要: |
| Objective To study the expression and significance of Cadherin11 (CDH11) in gastric cancer and explore the relation.ship between its expression difference and prognosis.Methods The change of CDH11 expression in gastric cancer was explored byOncomine database. The judgment value of CDH11 for prognosis of gastric cancer was explored by online database and analysis tool-"the KaplanMeier plotter" (KM plotter) database.Results Oncomine database contained 445 studies involved in different types of tu.mors. Among 66 studies, the difference of CDH11 expression was statistically significant (P<0. 05), and 59 studies showed increasedexpression of CDH11, 7 studies showed decreased expression of CDH11. A total of 85 studies, 8 data subsets involved the expression ofCDH11 in gastric cancer and normal tissues. A total of 478 samples showed that the expression of CDH11 in gastric cancer was signifi.cantly higher than that in normal tissues. In addition, analysis of KM plotter database showed the level of CDH11 was negatively corre.lated with overall survival in gastric cancer patients.Conclusion Compare with normal tissue, the level of CDH11 expression is signif.icantly higher in gastric cancer, and it was correlated with the prognosis of gastric cancer. CDH11 may be clinically used as an impor.tant target of medication for gastric cancer. |
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