| 赵磊,荆晓娟,蒋世杰.司来吉兰联合左旋多巴治疗帕金森病 51例[J].安徽医药,2022,26(2):406-409. |
| 司来吉兰联合左旋多巴治疗帕金森病 51例 |
| Selegiline combined with levodopa in the treatment of Parkinson's disease:51 cases |
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| DOI：10.3969/j.issn.1009-6469.2022.02.047 |
| 中文关键词: 帕金森病 司来吉兰 左旋多巴 帕金森综合评分量表评分 β淀粉样蛋白 1-42 平衡能力 |
| 英文关键词: Parkinson's disease Selegiline Levodopa Unified Parkinson's disease rating scale score β amyloid 1-42 Balance ability |
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| 中文摘要: |
| 目的观察司来吉兰联合左旋多巴治疗帕金森病( PD)的临床疗效及其对 PD病人帕金森病评分量表( UPDRS)评分、血清 β淀粉样蛋白 1-42(Aβ1-42)水平及平衡能力的影响。方法选取 2018年 6月至 2019年 8月在重庆医科大学附属遂宁市中心医院就诊的 PD病人 102例，采用随机数字表法分为观察组和对照组各 51例，对照组予以左旋多巴治疗，观察组予以司来吉兰联合左旋多巴治疗，治疗 2个月后进行疗效评价，并比较两组病人治疗前后血清 Aβ1-42水平、 UPDRS评分、 Berg平衡量表(BBS)评分、跌倒效能量表( MFES)评分、害怕跌倒( FOF)例数及生活质量综合评价量表( SF-36)评分变化情况。结果治疗后，观察组总有效率显著高于对照组( 94.12%比 76.47%，P<0.05)；治疗后观察组血清 Aβ1-42水平［( 1.32±0.42)μg/L比( 1.27± |
| 英文摘要: |
| Objective To observe the clinical efficacy of selegiline combined with levodopa in the treatment of Parkinson's disease(PD) and its influences on the Unified Parkinson's Disease Rating Scale (UPDRS) score, serum β amyloid 1-42 (Aβ1-42) level and bal. ance ability of PD patients.Methods One hundred and two patients with PD treated in Suining Central Hospital Affiliated to Chongq.ing Medical University from June 2018 to August 2019 were selected and randomly assigned into the observation group and the controlgroup by random digital table method, with 51 cases in each group. The control group was treated with levodopa, while the observationgroup was treated with selegiline and levodopa. The therapeutic effect was evaluated 2 months later, and the UPDRS score, serum Aβ1-42 level, balance ability and quality of life of the two groups were compared before and after treatment.Results After treatment, the to. tal effective rate of the observation group was significantly higher than that of the control group (94.12% vs. 76.47%, P<0.05); the level of serum Aβ1-42 [(1.32±0.42) μg/L vs. (1.27±0.45) μg/L], Berg Balance Scale (BBS) score [(47.05±4.16) score vs. (45.31±4.01) score], modified fall efficacy scale (MFES) score [(97.22±10.46) score vs. (89.52±10.75) score] and the MOS 36-item [(68.54±7.22) score vs. (61.37±7.46) score] short form health survey (SF-36) score in the observation group were higher than those in the control group, the UP. DRS score [(25.36±1.54) score vs. (31.33±1.62) score] and the number of FOF cases (8 cases vs. 18 cases) in the observation group were lower than those in the control group (P<0.05).Conclusion The effect of selegiline combined with levodopa in the treatment of PD issignificant, which can effectively alleviate the patient's condition and improve the clinical symptoms. |
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