| 余广兰,魏俊.乌灵胶囊对卒中后癫痫病人炎性因子及氧化应激水平的影响[J].安徽医药,2022,26(2):413-416. |
| 乌灵胶囊对卒中后癫痫病人炎性因子及氧化应激水平的影响 |
| Effect of Wuling capsule on inflammatory factor and oxidative stress level in post-stroke epilepsy patients |
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| DOI：10.3969/j.issn.1009-6469.2022.02.049 |
| 中文关键词: 癫痫 卒中 乌灵胶囊 炎性因子 氧化应激 |
| 英文关键词: Epilepsy Stroke Wuling capsule Inflammatory factor Oxidative stress |
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| 中文摘要: |
| 目的探讨乌灵胶囊对卒中后癫痫( PSE)病人的疗效、炎性因子、氧化应激及神经细胞因子水平的影响。方法回顾性分析 2015年 12月至 2018年 12月宜宾市第一人民医院收治的 120例 PSE病人的临床资料，按治疗方法不同分为观察组与对照组，各 60例。对照组口服左乙拉西坦片治疗，观察组在对照组基础上加用乌灵胶囊口服，两组均连续治疗 6个月。治疗后，比较两组临床疗效、血清炎性因子、氧化应激及神经细胞因子水平。结果治疗后，观察组总有效率高于对照组( 91.67%比 |
| 英文摘要: |
| Objective To explore the effect of Wuling capsule on the curative effect, inflammatory factors, oxidative stress and thelevel of neurocytokines in patients with post stroke epilepsy (PSE).Methods The clinical data of 120 patients with PSE in the FirstPeople's Hospital of Yibin from December 2015 to December 2018 were analyzed retrospectively. According to different treatmentmethods, the patients were divided into observation group and control group, with 60 cases in each group. The control group was treatedwith levetiracetam.The observation group was treated with Wuling capsule on the basis of the control group. Both groups were treatedcontinuously for 6 months. After treatment, the clinical efficacy, serum inflammatory factors, oxidative stress levels and neurocytokinefactors were compared between the two groups.Results After treatment, the total effective rate of the observation group was higher than that of the control group (91.67% vs. 76.67%, P<0.05). The levels of IL-1β, IL-6, IL-8 and TNF-α in the observation group [(12.32±4.40) vs. (17.51±5.39) pg/mL, (15.68±4.66) vs. (21.46±4.57) pg/mL,(10.57±4.53) vs. (16.36±4.96) pg/mL, (19.90±4.51) vs. (29.73±5.86) pg/mL] were lower than those in the control group (P<0.05). The levels of SOD and GSH-Px in the observation group [(129.15±11.42) vs. (97.21±9.12) U/mL, (78.50±9.06) vs. (59.11±6.96) U/L] were higherthan those in the control group, and the levels of MDA and MPO in the serum [(6.43±1.28) vs. (10.82±1.24) nmol/mL, (422.87±105.69) vs. (539.29±116.09) U/L] were lower than those in the control group (P<0.05). The levels of NSE, S100B in the observation group [(6.22±1.23) vs. (8.38±1.58) ng/mL, (0.13±0.03) vs. (0.21±0.08) ng/mL] were lower than those in the control group, and the level of BDNF [(26.23±4.31) vs. (22.90±4.48) ng/mL] were higher than those in the control group (P<0.05).Conclusion The adjuvant treatment of PSE with Wuling Capsule can improve thetreatment efficiency, and significantly reduce the release of inflammatory factors, the leveloxidative stress and nerve damage. |
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