| 王丽,唐旭,杨月君,等.ABCD2评分和血清血小板活化因子水平对短暂性脑缺血发作进展为脑梗死的诊断价值[J].安徽医药,2022,26(3):536-540. |
| ABCD2评分和血清血小板活化因子水平对短暂性脑缺血发作进展为脑梗死的诊断价值 |
| Diagnostic value of ABCD2 score combined with serum PAF for the progression of TIA to cerebral infarction |
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| DOI：10.3969/j.issn.1009-6469.2022.03.027 |
| 中文关键词: 脑缺血发作，短暂性 脑梗死 ABCD2评分 血小板活化因子 受试者工作特征曲线 危险分层 |
| 英文关键词: Ischemic attack, transient Cerebral infarction ABCD2 score Platelet activating factor ROC Risk stratification |
| 基金项目:保定市科技计划项目( 1951ZF019) |
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| 中文摘要: |
| 目的探讨 ABCD2评分和血清血小板活化因子( PAF)水平对短暂性脑缺血发作( TIA)进展为脑梗死中的诊断价值。方法选取 2016年 3月至 2019年 3月保定市第二医院 200例 TIA病人作为研究对象，其中 40例进展为脑梗死作为观察组， 160例未进展为脑梗死作为对照组。对比两组 ABCD2评分、血清 PAF水平、 TIA不同持续时间、发作次数病人 ABCD2评分、血清 PAF水平，分析 ABCD2评分与血清 PAF相关性及二者联合对 TIA进展为脑梗死的诊断价值，并分析不同危险分层 TIA病人脑梗死发生率( 2、7d)。结果观察组 ABCD2评分( 5.03±0.34)分、血清 PAF水平( 252.67±37.15)ng/L高于对照组( 3.21±0.38)分、(144.23±22.13)ng/L(P<0.05)；观察组 TIA不同持续时间( ≤10 min、>10~20 min、>20 min)病人 ABCD2评分［( 4.48±0.32)分比(5.12±0.35)分比( 5.79±0.28)分］、血清 PAF水平［( 219.32±40.69)ng/L比( 258.16±38.25)ng/L比( 298.68±41.31)ng/L］相比，差异有统计学意义( P<0.05)；观察组 TIA不同发作次数( 1次、 2~3次、 >3次)病人 ABCD2评分［( 4.52±0.37)分比( 5.04±0.32)分比 |
| 英文摘要: |
| Objective To explore the diagnostic value of ABCD2 score combined with serum platelet-activating factor (PAF) in the progression of transient ischemic attack (TIA) to cerebral infarction.Methods Two hundred patients with TIA treated in Baoding Second Hospital from March 2016 to March 2019 were selected as the research subjects, among whom 40 cases (observation group) progressed to cerebral infarction and the other 160 cases (control group) did not. A comparison was made of the ABCD2 scores, serum PAFlevels, different durations of TIA, and the number of episodes of patients with ABCD2 scores and serum PAF levels in the two groups.The correlation between ABCD2 score and serum PAF, the value of the combination of the two in the diagnosis of TIA progressing to cerebral infarction , and the incidences of cerebral infarction in TIA patients with different risk stratification (2, 7 d) were analyzed.Re? sults The ABCD2 score and serum PAF level in the observation group were higher than those in the control group [(5.03±0.34) vs. (3.21±0.38), (252.67±37.15) ng/L vs. (144.23±22.13) ng/L, respectively; P<0.05]. There were statistically significant differences amongpatients of the observation group with different durations of TIA (≤10 min, >10~20 min, >20 min) in ABCD2 scores [(4.48±0.32) points vs. (5.12±0.35) points vs. (5.79±0.28) points] and serum PAF levels [(219.32±40.69) ng/L vs. (258.16±38.25) ng/L vs. (298.68±41.31) ng/L] (P<0.05). There were statistically significant differences among patients of the observation group with different attack frequencies(once, twice-three times, > 3 times) in ABCD2 score [(4.52±0.37) points vs. (5.04±0.32) points, vs. (5.90±0.24) points] and serum PAF levels [(225.67±39.25) ng/L vs. (247.98±42.76) ng/L vs. (295.72±40.83) ng/L] (P<0.05). ABCD2 score in the observation group was positively correlated with serum PAF level (r=0.455, P=0.003). ABCD2 score combined with serum PAF level had a certain diagnostic val ue for the progression of TIA to cerebral infarction; with the increase of risk degree, the incidence of cerebral infarction in TIA patientscontinued to increase (P<0.05).Conclusion ABCD2 score and serum PAF level are abnormally high in patients with TIA progressingto cerebral infarction, and the combined detection is expected to become an important means for diagnosing the progression of TIA tocerebral infarction, judging the risk stratification, implementing targeted treatment programs, and reducing the incidence of short-term cerebral infarction. |
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