| 陈学兵,欧世梅,张利沙.胆固醇 7-羟化酶基因 rs4738687多态性与乙型肝炎病毒感染的相关性研究[J].安徽医药,2022,26(6):1147-1150. |
| 胆固醇 7-羟化酶基因 rs4738687多态性与乙型肝炎病毒感染的相关性研究 |
| Relationship between cholesterol 7-hydroxylase gene rs4738687 polymorphism and hepatitis B virus infection |
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| DOI：10.3969/j.issn.1009-6469.2022.06.020 |
| 中文关键词: 乙型肝炎病毒 胆固醇 7-羟化酶 rs473868位点 基因多态性 |
| 英文关键词: Hepatitis B virus Cholesterol 7-hydroxylase Rs473868 locus Gene polymorphism |
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| 中文摘要: |
| 目的探讨胆固醇 7-羟化酶(CYP7A1)基因 rs4738687多态性与乙型肝炎病毒( HBV)感染的相关性。方法回顾性选 |
| 英文摘要: |
| Objective To investigate the relationship between rs4738687 polymorphism of cholesterol 7-hydroxylase (CYP7A1) gene and hepatitis B virus (HBV) infection.Methods Two hundred patients (observation group) with HBV infection, who were treatedat Deyang People's Hospital from January 2015 to February 2019, were retrospectively selected, including 140 patients with chronicHBV infection and 60 patients with HBV-associated cirrhosis.Another 120 healthy people having check-up in the hospital were selected as control group. The rs4738687 polymorphism of CYP7A1 gene was detected by improved multiple high temperature ligase assay.Results There was no significant difference in the distribution of rs4738687 genotype and allele between the observation group andthe control group (P > 0.05). The percentage of AG + GG genotype at rs4738687 locus in the patients with HBV-associated cirrhosis in observation group was 90.00%, which was significantly higher than that in the patients with chronic HBV infection (35.00%, P<0.05).There were no significant differences in the proportion of AG + GG genotype at rs4738687 locus among the patients with different genders and ages in the observation group (P > 0.05).Conclusion The rs473868 polymorphism of CYP7A1 gene is not related to the susceptibility of HBV infection, but may be positively correlated with the occurrence of HBV-associated cirrhosis. |
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