| 白利君,杨波,刘荣新.经皮胃造瘘术联合特殊医学用途配方食品对晚期恶性肿瘤病人免疫功能及营养状况的影响[J].安徽医药,2022,26(6):1167-1170. |
| 经皮胃造瘘术联合特殊医学用途配方食品对晚期恶性肿瘤病人免疫功能及营养状况的影响 |
| Effects of percutaneous gastrostomy combined with formula food for special medical purposes on immune function and nutritional status in patients with advanced malignant tumors |
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| DOI：10.3969/j.issn.1009-6469.2022.06.025 |
| 中文关键词: 肠道营养 胃造口术 食品，配方 肿瘤 吞咽障碍 血管造影术，数字减影 经皮胃造瘘术 食品，专用 免疫功能 营养状况 指数， |
| 英文关键词: Enteral nutrition Gastrostomy Food, formulated Neoplasms Deglutition disorders Angiography, digital subtraction Percutaneous gastrostomy Foods, specialized Immune function Nutritional status |
| 基金项目:秦皇岛市科技计划项目( 201902A136) |
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| 中文摘要: |
| 目的观察数字减影血管造影(DSA)引导下经皮胃造瘘术联合特殊医学用途配方食品对吞咽障碍的晚期恶性肿瘤病 |
| 英文摘要: |
| Objective To observe the effects of DSA-guided percutaneous gastrostomy combined with formula food for special medical purposes on the immune function and nutritional status of patients with advanced malignant tumors with dysphagia.Methods A total of 100 dysphagia patients with advanced malignant tumors who underwent gastrostomy in Qinhuangdao Military Industrial Hospitalfrom January 2018 to January 2020 were selected and randomly divided into the observation group (2 cases of abscision, n=48) and the control group (3 cases of abscision, n=47) by using the random number table method. The observation group was treated with DSA guided percutaneous gastrostomy combined with special medical formula and the control group was treated with traditional gastrostomy. Thechanges of the levels of immune function and nutritional status of patients in the two groups were compared before treatment and 1month after treatment.Results Before treatment, there was no significant difference in the evaluation indexes of immune function andnutritional status between the two groups (P>0.05). After 1 month of treatment, the immune function indexes CD3+, CD4+, IgG, IgM and IgA in the observation group were higher than those before treatment, and the CD3+[(66.11±8.59) %], CD4+ [(38.87±8.61) %], IgG[(15.82±5.04) g/L], IgM [(1.44±0.46) g/L], IgA [(2.61±0.19) g/L] in the observation group were higher than those in the control group[(62.53±8.36) %, (35.41±7.31) %, (13.94±4.91) g/L, (1.26±0.41) g/L, (2.49±0.15) g/L], and the CD8+ was lower than that before treatment,andtheCD8+[(27.01±3.42)%]intheobservationgroupwaslowerthanthatinthecontrolgroup [(28.57±3.81)%](P<0.05). After1 month of treatment, the nutritional status evaluation indicators TSF, AMC, FFMI, Hb, ALB, PA in the observation group were higherthan those before treatment, and the TSF [(16.57±7.22) mm], AMC [(25.97±4.84) cm], FFMI [(18.82±3.74) kg/m2], Hb [(148.77±33.64)g/L], ALB [(43.76±7.97) g/L], PA [(347.46±83.64 ) mg/L] in the observation group were higher than those in the control group [(13.62±7.13) mm, (23.69±4.78) cm, (16.71±3.66) kg/m2, (131.81±30.19) g/L, (39.26±8.25) g/L, (309.83±79.61) mg/L] (P<0.05).Conclusions DSA-guided percutaneous gastrostomy combined with formula food for special medical purposes can effectively improve the immunefunction and nutritional status of patients with advanced malignant tumors with dysphagia. Clinical application is recommended. |
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