| 马庆华,马菲,李雪娟.变应性鼻炎病人血浆纤维胶凝蛋白 -3表达与补体 C3激活的关系[J].安徽医药,2022,26(7):1329-1332. |
| 变应性鼻炎病人血浆纤维胶凝蛋白 -3表达与补体 C3激活的关系 |
| Relationship between the expression of Ficolin-3 and the activation of complement C3 in patients with allergic rhinitis |
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| DOI：10.3969/j.issn.1009-6469.2022.07.013 |
| 中文关键词: 鼻炎，变应性，常年性 纤维胶凝蛋白 -3 补体 C3 相关性 |
| 英文关键词: Rhinitis,allergic,perennial Ficolin-3 Complement C3 Correlation |
| 基金项目:河南省医学科技攻关项目( 162102410022) |
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| 中文摘要: |
| 目的探讨变应性鼻炎病人血浆纤维胶凝蛋白 -3(Ficolin-3)表达与补体 C3激活的关系。方法选取郑州市第七人民医院 2017年12月至 2019年12月收治的 300例变应性鼻炎病人为观察组，另外选取 100例无过敏史的同期健康体检者作为对照组，采用酶联免疫吸附法(ELISA)检测血浆 Ficolin-3水平，采用免疫散射比浊法检测血清 C3水平，采用视觉模拟量表(VAS)评分评估变应性鼻炎病人严重程度。比较两组一般资料及 Ficolin-3、C3水平差异；采用 Spearman分析变应性鼻炎病人 Ficolin-3、C3水平相关性，及Fi-colin-3、C3水平与 VAS评分相关性；采用 logistic回归模型分析影响变应性鼻炎发生的因素。结果与对照组相比，观察组家族史、吸烟史、 C3水平［( 1.36±0.32)g/L、(1.03±0.24)g/L］均较高( P<0.05)Ficolin-3水平［( 11.72±2.24)mg/L、(15.69±2.86)mg/L］较低； Spearman相关分析显示，变应性鼻炎病人 Ficolin-3与C3水平、 VAS评分，均呈负相关(r=.0.67，r=.0.55，均P<0.05)，C3水平与 VAS评分呈正相关(r=0.57，P<0.05)；多因素 logistic回归分析结果显示，家族史、吸烟史、 C3高水平均是影响变应性鼻炎发生的危险因素(P <0.05)，Ficolin-3高水平是保护因素(P<0.05)。结论变应性鼻炎病人血浆 Ficolin-3水平与补体 C3激活及病情严重程度均相关，可能为变应性鼻炎的预防、评估提供临床参考依据。 |
| 英文摘要: |
| Objective To investigate the relationship between the expression of Ficolin-3 and the activation of complement C3 in pa-tients with allergic rhinitis.Methods A total of 300 allergic rhinitis patients admitted to the 7th People's Hospital of Zhengzhou from De-cember 2017 to December 2019 were selected as the observation group, and 100 healthy subjects with no history of allergies during thesame period were selected asthe controlgroup.PlasmaFicolin-3levels were detectedby enzyme-linked immunosorbentassay (ELISA), se-rum C3 levels were detected by immune turbidimetry, and the severity of allergic rhinitis was assessed by visual analog scale (VAS). Thegeneral data, and the differences in Ficolin-3 and C3 levels between the two groups were compared; Spearman's test was used to analyze the correlation between the levels of Ficolin-3 and C3 in patients with allergic rhinitis and the correlation between Ficolin-3 and C3 and the VAS score. A logistic regression model was used to analyze the influencing factors in the development of allergic rhinitis.Results Com-pared with the control group, the family history, smoking history, and C3 level of the observation group [(1.36±0.32) g/L, (1.03±0.24) g/L]were higher (P<0.05), and Ficolin-3 levels [(11.72±2.24) mg/L, (15.69±2.86) mg/L] were lower. Spearman correlation analysis showed that allergic Ficolin-3 was negatively correlated with the C3 level and VAS score in rhinitis patients (r=.0.67,r=.0.55,All P<0.05), and the C3 level was positively correlated with the VAS score (r=0.57,P<0.05). Multivariate logistic regression analysis showed that family history,smoking history and high levels of C3 were the risk factors for allergic rhinitis (P<0.05), and high levels of Ficolin-3 were protective factors (P<0.05).Conclusion The plasmaFicolin-3 levelinpatientswithallergic rhinitisisrelatedtotheactivation ofcomplementC3 andthese-verityofthedisease,whichmayprovideaclinicalreferencefortheprevention andevaluationofallergic rhinitis. |
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