| 赵东军,王晗,杨森,等.抗生素骨水泥填充技术联合自体富血小板血浆对慢性创面修复效果及病人生活质量的影响[J].安徽医药,2022,26(8):1558-1561. |
| 抗生素骨水泥填充技术联合自体富血小板血浆对慢性创面修复效果及病人生活质量的影响 |
| Eeffect of antibiotic bone cement filling technique combined with autogenous platelet-rich plasma on the effect of chronic wound repair and the quality of life of patients |
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| DOI：10.3969/j.issn.1009-6469.2022.08.017 |
| 中文关键词: 伤口愈合 慢性创面 Masquelet技术 富血小板血浆 细胞增殖 修复疗效 生活质量 |
| 英文关键词: Wound healing Chronic wound Masquelet technique Platelet-rich plasma Cell proliferation Repair effect The quality of life |
| 基金项目:陕西省卫健委科研基金项目(2018D014)；安康市科技局科研课题基金项目(2018AK03-07) |
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| 中文摘要: |
| 目的探讨抗生素骨水泥填充技术(Masquelet)联合自体富血小板血浆(PRP)对慢性创面修复效果及病人生活质量影响。方法选择2018年1月至2018年10月安康市中医医院创伤整形科收治的慢性创面病人60例，按照治疗方法不同分为观察组30例及对照组30例；对照组病人创面清创后以PRP外敷治疗，观察组病人创面清创后先行Masquelet技术，后行PRP治疗。比较两组慢性创面病理切片中真皮细胞DNA含量、创面缩小率、细菌清除率、肉芽组织覆盖率、肉芽组织厚度以及治疗后生活质量(SF-36)评分。结果治疗后，观察组的创面病理切片中真皮细胞DNA含量为(27.56±1.23)，明显多于对照组(24.26±0.53)，P<0.05；观察组创面缩小率明显大于对照组［(82.25±9.68)%比(55.58±7.53)%，t=12.01，P<0.01］；观察组细菌清除率明显高于对照组［(86.23±8.58)%比(76.01±7.56)%，t=11.24，P<0.01］；观察组肉芽组织覆盖率明显高于对照组［(88.56±9.78)%比(66.58±6.54)%，t=10.33，P<0.01］；观察组肉芽组织生长厚度明显厚于对照组［(6.58±0.21)mm 比(4.19±0.37)%，t=19.26，P<0.01］；治疗3个月后观察组SF-36评分高于对照组［(81.20±4.01)分比(71.50±5.19)%，t=5.66，P<0.01］。结论Masquelet技术联合PRP治疗慢性创面，可促进创面愈合，改善病人生活质量，可临床推广。 |
| 英文摘要: |
| Objective To investigate the effect of antibiotic bone cement filling technique (Masquelet) combined with autogenous platelet-rich plasma (PRP) on the effect of chronic wound repair and the quality of life of patients.Methods From January 2018 to Oc?tober 2018,60 patients with chronic wounds admitted to the Trauma Orthopedics Department of Ankang Hospital of Traditional Chinese Medicine were selected and randomly divided into observation group and control group according to different treatment methods.Pa?tients in the control group were treated externally with PRP after wound debridement,while patients in the observation group were first treated with Masquelet technology after wound debridement,followed by PRP treatment.Dermal cell DNA content,wound reduction rate, |
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